grant
Core D: Mucus Biochemistry and Biophysics Core
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 30 Sept 2003Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AccelerationAdhesionsAdvisory ServicesAffectAirway failureAlimentary CanalAnimalsAnti-F19 Monoclonal AntibodyAnti-FAP (Fibroblast Activation Protein), F19 Epitope, Monoclonal AntibodyAntibodiesAssayAtomic Force MicroscopyAutomobile DrivingAwardBicarbonatesBioassayBiochemicalBiochemistryBiogenesisBiologic ModelsBiological AssayBiological ChemistryBiological ModelsBiophysicsBiopsyBody TissuesCF mucusCF patientsCFTRCFTR ProteinCell BodyCell Culture TechniquesCell modelCell surfaceCellsCellular biologyCellular modelCervical MucusCervix MucusChloridesClinicalClinical ResearchClinical ServicesClinical StudyCommunicationComplexCulturing, in vitro Vertebrate, PrimaryCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDNADNA TherapyDeoxyribonucleic AcidDevelopmentDigestive TractDirect CostsDiseaseDisease ProgressionDisorderDoctor of PhilosophyDomestic RabbitDysfunctionEpithelial CellsEpitheliumEvaluationF19FISH TechnicFISH TechniqueFISH analysisFISH assayFacultyFluorescence In Situ HybridizationFluorescent in Situ HybridizationForce MicroscopyFrictionFunctional disorderFundingGI TractGastrointestinal TractGastrointestinal tract structureGene Therapy AgentGene Therapy VectorsGene Transduction AgentGene Transduction VectorsGene Transfer ClinicalGeneticGenetic InterventionGoalsGut EpitheliumHCO3HealthHistoryHumanHydrogen CarbonatesImageImmunologyImpairmentIn VitroIn vivo analysisInfectionInflammationInternationalIntestinalIntestinesInvestigatorsIon TransportLabelLavageLungLung Respiratory SystemMG1MR ImagingMR TomographyMRIMRIsMUC-1MUC1MUC1 gene productMUC2MUC5ACMUC5AC geneMUC5BMUC5B geneMagnetic Resonance ImagingMeasurementMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodologyMethodsMiceMice MammalsMicrobiologyMoAb F19Model SystemModelingModern ManMolecularMolecular WeightMonoclonal Antibody F19Muc1 MucinMucin 1Mucin 1 proteinMucin 2Mucin-2 Staining MethodMucinsMucous body substanceMucoviscidosisMucusMucus GlycoproteinMurineMusNMR ImagingNMR TomographyNatureNormal RangeNormal ValuesNuclear Magnetic Resonance ImagingOrganOrigin of LifeOryctolagus cuniculusOsmotic PressurePancreasPancreaticPathogenesisPathologyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPersonsPh.D.PhDPhysiologyPhysiopathologyPositionPositioning AttributePrimary Cell CulturesPropertyPulmonary Body SystemPulmonary Organ SystemRabbitsRabbits MammalsReagentRecording of previous eventsResearchResearch PersonnelResearch SpecimenResearchersRespiratory EpitheliumRespiratory FailureRespiratory SystemRespiratory TractsRespiratory tract structureRoleSamplingScanning Electron MicroscopyScanning Force MicroscopyServicesSpecimenSputumStructure of respiratory epitheliumStudy modelsSurfaceSymptomsSystemTechniquesTechnologyTherapeutic AgentsTherapeutic EffectTherapeutic InterventionTissuesTrainingTranslationsTransmission Electron MicroscopyZeugmatographyairway epitheliumalimentary tractbasebasesbiomarker developmentbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbowelcareercell biologycell culturecell culturesclinical translationclinically translatableconfocal imagingcystic fibrosis mucuscystic fibrosis patientscystic fibrosis transmembrane regulatordepositorydesigndesigningdevelopmentaldigestive canaldrivingdrug candidateextracellulargastrointestinalgastrointestinal epitheliumgene manipulationgene repair therapygene therapeuticsgene therapygene-based therapeuticgene-based therapeuticsgene-based therapygenes therapeuticgenes therapeuticsgenetic manipulationgenetic therapygenetically manipulategenetically perturbgenital tractgenomic therapyhistologic imagehistological imagehistoriesimagingimaging approachimaging based approachimprovedin vitro Assayin vitro Modelin vivoin vivo evaluationin vivo testingindividuals with CFindividuals with cystic fibrosisinfection recurrenceinnovateinnovationinnovativeinnovative technologiesinsightintervention therapylavage therapymembermolecular sizemucousmucus clearancenew drug treatmentsnew drugsnew markernew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel biomarkernovel drug treatmentsnovel drugsnovel imaging technologynovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpathophysiologypatient oriented outcomespatients with CFpatients with cystic fibrosispersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpre-clinicalpreclinicalprogramsrecruitrecurrent infectionrecurring infectionrepositoryreproductive tractrespiratoryrespiratory tract epitheliumsocial rolesynergismtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttesting servicestherapeutic agent developmenttherapeutic biomarkertherapeutic developmenttherapeutic genetherapeutic markertissue culturetranslationventilationzeta potential
Description preview
The UNC Cystic Fibrosis Research and Translation Core Center (CFRTCC) has the long-term goal to achieve a systemic cure for cystic fibrosis (CF) across the gastrointestinal (GI) tract, pancreas, and lungs and thus aims to synergize and accelerate CF therapeutic development. Our CF research base is extensive, with 120 faculty members specializing…
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