grant
Core D: Animal Production Core
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 12 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20253-O-alpha-D-galactosylgalactoseAPC receptorAb-mediated immunityAb-mediated protectionAllelesAllelomorphsAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibody immunityAntibody protectionAntibody-mediated protectionAnticoagulant AgentsAnticoagulant DrugsAnticoagulantsAntigensApplications GrantsB7-H1BaboonsBindingBlood PlateletsBlood monocyteCD 46 antigenCD274CD46CD46 AntigenCD47CD47 AntigenCD47 GlycoproteinCD47 geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCardiac TransplantationCas nuclease technologyCell BodyCellsClinicalClottingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoagulationCoagulation ProcessCollaborationsComplementComplement ProteinsEPCREPCR geneEndothelial CellsEndothelial protein C receptorEvaluationExonsF8VWFFamily suidaeFutureGal alpha(1,3)GalGal-1-3-GalGalalpha(1,3)GalGalalpha1-3GalGenerationsGenesGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenotypeGlobulinsGoalsGrafting ProcedureGrant ProposalsGrowth Hormone ReceptorH-D AntigensHO-1 enzymeHO1HO2HSP32Hanganutziu-Deicher AntigensHeartHeart GraftingHeart TransplantationHeteroantigensHeterogenetic AntigensHeterograftHeterologous AntigensHeterologous TransplantationHeterophil AntigensHeterophile AntigensHumanHuman Growth HormoneImmuneImmune TargetingImmunesIn VitroInjuryInnate ImmunityIntegrin-Associated ProteinKidneyKidney Urinary SystemKnock-outKnockoutLifeLiverLungLung GraftingLung Respiratory SystemLung TransplantationMCP antigenMER6Marrow monocyteMarrow plateletMasksMediatingModern ManModificationMolecular InteractionNHP modelsNIAIDNational Institute of Allergy and Infectious DiseaseNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityOrganOrgan DonorOrgan TransplantationOrgan TransplantsPD-L1PDL-1PapioPathogenicityPaul-Bunnell AntigensPerfusionPhenotypePigsPlateletsProductionProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1Pulmonary GraftPulmonary TransplantPulmonary TransplantationReceptor GeneRecombinant DNA TechnologyRegulator GenesResearchRoleSerum GlobulinsSomatotropin (Human)Somatotropin ReceptorSomatotropin ReceptorsSomatropinSomatropin (Human)SourceSuidaeSurface Antigen Identified by Monoclonal Antibody 1D8SwineSystemT-Cell ActivationTechniquesTestingThrombocytesThrombomodulinThrombosisThymotaxinTissue TransplantationTranscriptional Regulatory ElementsTransferaseTransferase GeneTransgenesTransgenic OrganismsTranslationsTransplantationVWF geneWorkXenoantigensXenogeneic AntigensXenogenic AntigensXenograftXenograft procedureXenotransplantationactivate T cellsactivated protein C receptorantibody-mediated immunitybeta-2 Microglobulinblood thinnercardiac graftclinical applicabilityclinical applicationcomplementationdesigndesigningendothelial cell protein C receptorex vivo perfusionexperimentexperimental researchexperimental studyexperimentsexpression vectorgalactose alpha 1-3 galactosegalactosyl-(1-3)galactosegalactosyl-alpha-(1-3)galactosegene editing platformgene editing systemgene editing technologygene editing toolsgene manipulationgene-editing toolkitgenetic manipulationgenetic trans acting elementgenetically engineeredgenetically manipulategenetically perturbhGHhGH (Human Growth Hormone)heart transplantheme oxygenase-1hemeoxygenase 1hepatic body systemhepatic organ systemimmunogenimmunogenicinjuriesisletknockout genelung transplantmembermembrane cofactor proteinmonocytenext generationnon-human primatenonhuman primatenonhuman primate modelsorgan allograftorgan developmentorgan graftorgan growthorgan xenograftpig genomeporcinepre-clinicalpre-clinical studypreclinicalpreclinical studypreventpreventingprogrammed cell death ligand 1programmed cell death protein ligand 1programspromoterpromotorprotein death-ligand 1regulatory generenalsocial rolesomatic cell nuclear transfersugarsuidthrombopoiesis inhibitorthrombotic diseasethrombotic disordertrans acting elementtransgenetransgenictranslationtransplantvWFxeno-transplantxeno-transplantationβ2 Microglobulin
Description preview
ABSTRACT
Genetic manipulation of the pig genome through a combination of sophisticated gene editing tools and somatic
cell nuclear transfer and offers the opportunity to provide an unlimited source of human-compatible donor
organs, cells, and tissues for transplantation. As the Pig Core, Revivicor will apply their advanced transgenic
pig…
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