grant
CORE C - COMPUTATIONAL BIOCHEMISTRY & BIOINFORMATICS
Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 9 Aug 2019Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAccelerationAdvanced DevelopmentAssayAtlasesBindingBioassayBiochemicalBiochemistryBioinformaticsBiologicalBiological AssayBiological ChemistryBiologyBiophysicsBurkitt HerpesvirusBurkitt Lymphoma VirusCancer BiologyCancersCell BodyCell LineCellLineCellsChemicalsClinical DataCommunitiesComparative Genomic AnalysisComplexComputer ModelsComputerized ModelsComputing MethodologiesCytosine AminohydrolaseCytosine deaminaseDNA mutationDNA-Dependent RNA Polymerase IIDataData ScienceData SetDevelopmentDrug KineticsDrugsEB virusEBVEffectivenessEnsureEnzyme GeneEnzymesEpstein Barr VirusEvolutionFAIR dataFAIR guiding principlesFAIR principlesFindable, Accessible, Interoperable and Re-usableFindable, Accessible, Interoperable, and ReusableFree EnergyGene ExpressionGenerationsGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenomicsGoalsHHV-4HHV4HerpesviridaeHerpesvirusesHumanHuman Herpesvirus 4Infectious Mononucleosis VirusInformaticsInternationalKineticsLengthLigandsLungLung Respiratory SystemMacromolecular ComplexesMalignant NeoplasmsMalignant TumorMedicationMethodsModelingModern ManModernizationMolecularMolecular Dynamics SimulationMolecular InteractionMutagenesisMutagenesis Molecular BiologyMutationNGS MethodNGS dataNGS systemNucleic AcidsOutcomePharmaceutical PreparationsPharmacokineticsPropertyProteinsRNA Polymerase BRNA Polymerase IIReceptor ProteinRegulationReproducibilityRoentgen RaysRoleSequence Read ArchiveShort Read ArchiveSingle-Stranded DNASourceSpecificitySpinal ColumnSpineStrains Cell LinesStructural ModelsStructureSystemTCGATechniquesTestingThe Cancer Genome AtlasThermodynamicThermodynamicsTimeTumor PromotionVHHVHH antibodyVertebral columnX-RadiationX-Ray RadiationX-rayXrayadvanced simulationanti-cancer researchbackbonebiologicbiophysical foundationbiophysical modelbiophysical principlesbiophysical sciencescamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincancer cell genomecancer genomecancer researchchemical bindingchemical boundchemical synthesiscomparativecompound optimizationcomputational chemistrycomputational methodologycomputational methodscomputational modelingcomputational modelscomputer based methodcomputer based modelscomputer methodscomputerized modelingcomputing methodcultured cell linedata integrationdata modelingdata re-usedata reusedata-driven modeldatabase of Genotypes and PhenotypesdbGaPdesigndesigningdevelopmentaldrug/agentexperimentexperimental researchexperimental studyexperimentsformulation optimizationgenome mutationgenomic datagenomic datasetherpes virushuman dataimprovedin silicoinhibitorinnovateinnovationinnovativeinsightlab assignmentlab experimentlaboratory activitylaboratory assignmentlaboratory exerciselaboratory experimentlarge data setslarge datasetslead optimizationmalignancymodel developmentmodel developmentsmodel of datamodel the datamodeling of the datamolecular dynamicsmolecular recognitionmouse modelmulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultidisciplinarymultiscale computational modelingmultiscale mathematical modelingmultiscale modelingmurine modelnano engineeringnanobodiesnanobodynanoengineeringneoplasm/cancernext gen sequencingnext generation sequence datanext generation sequencingnextgen sequencingnoveloperationoperationspeptide mimeticpeptide mimicpeptidomimeticsprecancerprecancerouspremalignantpreventpreventingprocess optimizationprogramspublic data basepublic databasepublicly accessible data basepublicly accessible databasepublicly available data basepublicly available databasereceptorresidenceresidential buildingresidential siteresistance mutationresistant mutationsdAbsimulationsingle domain antibodiessmall moleculesocial rolessDNAstructural biologythree dimensionalthree-dimensional modelingtumor genomevariable heavy chain antibody
Description preview
CORE C – COMPUTATIONAL CHEMISTRY, BIOPHYSICS & BIOINFORMATICS
ABSTRACT
APOBEC is a well-established enzymatic source of on-going mutation in cancer. The major enzymes
responsible are the cytosine deaminases APOBEC3A (A3A) and APOBEC3B (A3B), which attack the single-
stranded (ss)DNA. Our Program is therefore united in testing the overarching…
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