grant
CORE B: Viral Assays Core
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 29 Jul 2015Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years old9 year old9 years of ageAbscissionAddressAdultAdult HumanAdverse reactionsAmino AcidsAntibodiesAntibody ResponseAntibody titer measurementAntigenic DeterminantsAntigensArboviralArbovirusesArthropod-Borne VirusesAssayAttenuated VaccinesBindingBinding DeterminantsBioassayBiological AssayBlood SerumBreakbone Fever VirusCell LineCellLineChildChild YouthChildhoodChildren (0-21)ClinicalClinical Treatment MoabCohort StudiesCollaborationsCollectionCommunitiesComplexConcurrent StudiesCountryCoupledDENVDENV infectionDENV vaccineDataDengueDengue InfectionDengue VaccineDengue VirusDengue fever virusDengue virus infectionDengue virus vaccineDengvaxiaDevelopmentDiseaseDisorderEffectivenessEpidemiologyEpitope MappingEpitopesExcisionExtirpationFingerprintFlaviviridaeFlavivirusFutureGenerationsGenetics-MutagenesisGenotypeGlycoproteinsGoalsGrantGroup B ArbovirusHealthHu-mABsHumanImmuneImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualInfectionInvestigatorsLaboratoriesLicensingLicensureLive-attenuated VaccineMapsMeasurableMeasuresMembraneMethodologyModern ManMolecularMolecular InteractionMonoclonal AntibodiesMutagenesisMutagenesis Molecular BiologyNational Institutes of HealthNatureNicaraguaNicaraguanNorth CarolinaOrthoflavivirusOutcomeP01 MechanismP01 ProgramPathogenesisPathogenicityPerformancePhilipinesPhilippinesPhillipinesPhillippinesPopulationPreparednessPrimary InfectionProbabilistic ModelsProbability ModelsProgram Project GrantProgram Research Project GrantsProtocolProtocols documentationPublic HealthReadinessReagentRemovalReporterResearch PersonnelResearch Program ProjectsResearchersResolutionResource DevelopmentRiskRoleRunningSafetySamplingSerologySerotypingSerumShapesStatistical ModelsStrains Cell LinesStructure-Activity RelationshipSurfaceSurgical RemovalSystemTestingTherapeutic antibodiesTimeTranslatingUnited States National Institutes of HealthUniversitiesVaccinatedVaccinationVaccineeVaccinesValidationVariantVariationViralViral DiseasesVirusVirus Diseasesadaptive immunityadulthoodage 9 yearsagedaminoacidantibody titeringchemical structure functioncohortcost effectivecross reactivitycultured cell linedengue viral infectiondeploy vaccinesdesigndesigningdevelopmentaldimerdistribute vaccinesepidemiologicepidemiologicalglycoprotein structurehesitant to vaccinationhost responsehumAbshuman mAbshuman monoclonal antibodieshuman monoclonalsimmune system responseimmunogenimmunoresponseimprintimprovedinsightkidslive vaccinelive vaccinesmAbsmembrane structuremonoclonal Absmosquito-bornemosquitobornemutation scanningmutation screeningneutralizing antibodynine year oldnine years of agenovelpandemicpandemic diseasepediatricprogramsresectionresolutionsresponsereverse geneticsseropositivesevere denguesocial rolestatistical linear mixed modelsstatistical linear modelsstemstructure function relationshiptoolvaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccination hesitancyvaccine against DENVvaccine against denguevaccine candidate against denguevaccine deploymentvaccine distributionvaccine hesitancyvaccine hesitantvaccine roll-outvaccine rolloutvalidationsviral infectionvirus infectionvirus-induced diseaseyoungster
Description preview
SUMMARY:
Dengue viruses (DENV) are responsible for the most significant mosquito-borne viral disease in humans, causing
over 100 million infections and ~50 million dengue cases annually worldwide. The complexity of the immune
response to four related serotypes (DENV1-4) and lack of reliable correlates of protection have hindered efforts
to…
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