grant
Core B - Sequencing, Genotyping and Automated Mapping
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 13 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20251-Ethyl-1-nitrosoureaAgeAllelesAllelomorphsAssayAttentionBar CodesBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood capillariesBreedingBrittle Diabetes MellitusCell BodyCellsChemistryCodeCoding SystemComputer Software ToolsComputer softwareComputersCustomDNADNA mutationDataData BasesDatabasesDeoxyribonucleic AcidDetectionDevelopmentDiabetes MellitusENUEpistasisEpistatic DeviationEthylnitrosoureaFailureFemaleGene AlterationGene MutationGenesGenetic ChangeGenetic EpistasisGenetic defectGenetic mutationGenetics-MutagenesisGenomic DNAGenotypeGerm LinesGlycosuriaHeterozygoteHomozygoteIDDMImmune systemImmunochemical ImmunologicImmunologicImmunologic TestsImmunologicalImmunological TestsImmunologicallyImmunologicsIndividualInduced DNA AlterationInduced MutationInduced Sequence AlterationInsulin-Dependent Diabetes MellitusInteraction DeviationIonsJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLaboratory PersonnelLightMachine LearningMapsMeiosisMiceMice MammalsMissionMurineMusMutagenesisMutagenesis Molecular BiologyMutant Strains MiceMutationMutation DetectionN-Ethyl-N-nitrosoureaN-ethyl-N-nitroso-ureaNitrosoethylureaNucleotidesPedigreePhenotypePhotoradiationProcessRNA SplicingSiteSoftwareSoftware ToolsSplice-Junction MutationSplice-Site MutationSplicingSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMTargeted ResequencingTechnologyTerminologyTrainingTransmissionType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusWeaningWritingagesarmbarcodecapillarycarrier statuscausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcustomsdata basedevelopmentaldiabeteselectronic dataepistatic interactionepistatic relationshipexome sequencingexome-seqexperiencegDNAgene defectgene x gene interactiongenetic epistasesgenetic pedigreegenome mutationheterozygosityinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmachine based learningmeioticmouse mutantmutant alleleparagonpedigree structurephenotypic dataprogramsscreeningscreeningssequencing platformsoftware toolkittransmission processtype I diabetestype one diabetes♀
Description preview
PROJECT SUMMARY/ABSTRACT
Highly trained and experienced Core B laboratory personnel will be responsible for automated meiotic mapping
(AMM) of mutations that alter the T1D phenotype in NOD/NckH mice (either suppressing or augmenting the
normal course of T1D development). AMM is necessary for the rapid identification of single nucleotide changes…
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