grant
CORE B – PROTEINS & ASSAYS
Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 9 Aug 2019Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AntibodiesAssayBindingBioassayBiochemicalBiological AssayBiophysicsCalorimetryCancer TreatmentCancersCell BodyCellsCellular AssayChargeChemicalsClinical Treatment MoabCollaborationsCommunitiesComplementComplement ProteinsComplexCoupledCustomCytosine AminohydrolaseCytosine deaminaseDNADNA mutationDataDeaminaseDeaminationDeoxyribonucleic AcidDetectionDevelopmentDrug resistanceELISAEnsureEnzyme GeneEnzyme-Linked Immunosorbent AssayEnzymesEvolutionFamilyFamily memberFluorescenceFundingGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGoalsHumanImageImmunoblottingIn VitroIndustryInsectaInsectsInsects InvertebratesInvadedMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiniaturisationsMiniaturizationModern ManMolecularMolecular InteractionMonoclonal AntibodiesMutagenesisMutagenesis Molecular BiologyMutateMutationNeoplasm MetastasisNucleic AcidsOligoOligonucleotidesOutcomePhotometryPrimary NeoplasmPrimary TumorProceduresProcessProductionProteinsPublicationsRNA EditingRNA, Messenger, EditingReaderReagentRecombinant ProteinsReproducibilityResearchResolutionScanningScientific PublicationSecondary NeoplasmSecondary TumorServicesSingle-Stranded DNAStandardizationStructureSurface Plasmon ResonanceTestingTimeTitrationsVHHVHH antibodyValidationVirusWestern BlottingWestern ImmunoblottingWorkanti-cancer researchanti-cancer therapybiophysical foundationbiophysical principlesbiophysical sciencescamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincancer metastasiscancer researchcancer therapycancer-directed therapycell assaycomplementationcostcustomsdevelopmentaldrug resistantendonucleaseenzyme linked immunoassaygenome mutationimaginginhibitormAbsmalignancymembermilligrammonoclonal Absmultidisciplinarymutantnanonanobodiesnanobodyneoplasm/cancernoveloligospreventpreventingprogramsprotein blottingprotein expressionreagent standardizationresistance to Drugresistance to therapyresistant to Drugresistant to therapyresolutionssdAbsingle domain antibodiessmall moleculessDNAstructural biologytherapeutic resistancetherapy resistanttooltreatment resistancetumortumor cell metastasisvalidationsvariable heavy chain antibody
Description preview
CORE B – PROTEINS & ASSAYS
ABSTRACT
The APOBEC3 (A3) family of single-stranded DNA-cytosine deaminases function normally to defend cells
from invading viruses. Overwhelming evidence implicates at least two of these family members, APOBEC3A
(A3A) and APOBEC3B (A3B), in causing mutagenesis in a wide variety of primary cancers, with metastases…
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