grant
Core B - Microbial glycan microarray core
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025ABH Blood GroupABO blood group systemABO blood groupsABO(H) blood groupsAb responseAntibodiesAntibody FormationAntibody ProductionAntibody RepertoireAntibody ResponseAntigensAreaAssessment instrumentAssessment toolAutomobile DrivingBindingBiomedical ResearchBlood Group AntigensBlood GroupingBlood TypingBlood typing procedureCarbohydratesClinicalComplexComplex MixturesD-Galactoside-Binding LectinDataDevelopmentExposure toGalactose Binding LectinGalaptinsGalectinsGlycansGoalsGroup StructureH Blood GroupH Blood Group SystemImmuneImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic Factor InteractionImmunologic FactorsImmunologicalImmunological FactorsImmunologicallyImmunologicsIndividualLigandsLinkMediatingMicrobeMolecular InteractionOutcomeP01 MechanismP01 ProgramPlayPolysaccharidesPopulationPrintingProductionProgram Project GrantProgram Research Project GrantsProtein-Carbohydrate InteractionProteinsReproducibilityResearch Program ProjectsResearch ResourcesResourcesRoleS-Type LectinsSamplingShapesSiteSpecificityTestingTransfusionTransplantationTriageValidationVariantVariationantibody biosynthesisbeta-D-Galactosyl-Specific Lectinbeta-Galactoside Binding Lectinblood groupcarbohydrate binding proteincarbohydrate receptorcommunity microbesdevelopmentaldrivinghigh throughput analysishost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionsimmunogenimmunoglobulin biosynthesisimmunologic substanceimmunological substanceinsightmicrobe communitymicrobialmicrobial communitymicrobial hostmicrobial interactionmicroorganism communitymicroorganism interactionnew approachesnovelnovel approachesnovel strategiesnovel strategypolymicrobial communityprogramsprotein bound carbohydratesocial roletooltransplantvalidations
Description preview
SUMMARY: Naturally occurring anti-ABO(H) antibodies represent the most common barrier to transfusion and
transplantation. These antibodies can vary wildly in titer and specificity, resulting in distinct clinical outcomes
following ABO(H) incompatibility. Formation of these antibodies is linked directly to host interaction with specific
microbial…
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