grant
Core B - Clinical Core
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 May 2019Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202621+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD and related dementiaAD biological markerAD biomarkerAD dementiaAD pathologyAD related biomarkerAD related dementiaADRDAdultAdult HumanAged 65 and OverAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related biomarkerAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimer's related biomarkerAlzheimers DementiaAlzheimer’s biological markerAmentiaAmyloidAmyloid SubstanceBiologicalBiological MarkersBloodBlood Reticuloendothelial SystemBlood TestsBlood VesselsBrainBrain Nervous SystemCare GiversCaregiversCaringCausalityCerebrospinal FluidCharacteristicsClinicalClinical DataClinical EvaluationClinical ResearchClinical StudyClinical TestingClinical assessmentsCognitiveCollaborationsCollectionCommunitiesConsentCoupledDNADNA MarkersDNA biomarkersDataData CollectionData Management and Analysis CoreData Management and Statistical Analysis CoreData Management and Statistical CoreDementiaDeoxyribonucleic AcidDevelopmentDisciplineDisclosureDrugsEarly DiagnosisEarly InterventionEducationEducation and OutreachEducational aspectsElectronic Health RecordEncephalonEnrollmentEnsureEtiologyFacultyFeedbackFosteringFundingGoalsGrantHealthHematologic TestsHematological TestsHematology TestingIndividualInformation DisclosureInstruction and OutreachInvestigatorsLewy BodiesLife CycleLife Cycle StagesLinkLiquid substanceMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMeasuresMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMissionNMR ImagingNMR TomographyNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingPETPET ScanPET imagingPETSCANPETTParticipantPathologyPatientsPersonsPharmaceutical PreparationsPhenotypePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProbabilistic ModelsProbability ModelsProcessQuestionnairesRad.-PETResearchResearch PersonnelResearch ResourcesResearchersResourcesScientistServicesStandardizationStatistical ModelsSyndromeTest ResultTrainingTraining and OutreachTutoring and OutreachWisconsinWorkZeugmatographyabove age 65adulthoodafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65aging associatedaging relatedbio-markersbiologicbiologic markerbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseasecausationcerebral spinal fluidclinical centerclinical testco-morbidco-morbiditycognitive assessmentcognitive testingcohortcommunity level disadvantagecommunity partnershipcomorbiditydata sharingdementia caredepositorydevelopmentaldisadvantaged communitydisease causationdrug/agentearly detectioneducation researchelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordenrollexperienceexposomefaculty mentorfluidfunctional outcomeshuman old age (65+)implementation facilitationinvestigate longitudinallife courselife-style factorlifestyle factorslimbic-predominant age-related TDP-43 encephalopathylimbic-predominant age-related TDP43 encephalopathyliquidlongitudinal investigationlongitudinal researchmicrotubule bound taumicrotubule-bound taumid lifemid-lifemiddle agemiddle agedmidlifemild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmulti-modalitymultidisciplinarymultimodalityneighborhood barrierneighborhood disadvantageneighborhood-level barrierneighborhood-level disadvantageneural imagingneuro-imagingneurobehavioralneurobehavioral symptomneuroimagingneurological imagingneuropathologicneuropathologicalneuropathologyneuropsychologicnext generationnoveloutreachover 65 yearspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpreclinicalpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprimary degenerative dementiarecruitrepositoryresearch clinical testingscreeningscreeningssenile dementia of the Alzheimer typesocial health determinantssocio-economicsocio-economicallysocioeconomicallysocioeconomicsspinal fluidstatistical linear mixed modelsstatistical linear modelsstudy longitudinalsurvey longitudinaltautau Proteinstau factortoolvascularτ Proteins≥65 years
Description preview
REVISED PROJECT SUMMARY – CLINICAL CORE (CORE B) The primary objective of the Wisconsin Alzheimer’s Disease Research Center (ADRC) Clinical Core is to provide access to well-characterized participants with standardized clinical, cognitive, and neurobehavioral data coupled with neuroimaging (magnetic resonance imaging [MRI], positron emission…
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