grant
Core B: Animal Models
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 15 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AccelerationAccessory SinusesAddressAirAirway failureAirway infectionsAnimal ModelAnimal Models and Related StudiesAnimalsAssayBioassayBiologicalBiological AssayBloodBlood Reticuloendothelial SystemBronchoalveolar Lavage FluidCaringCiliaConsultationsDNA mutationData AnalysesData AnalysisData SetData Storage and RetrievalDiseaseDisease ProgressionDisorderDyneinDynein ATPaseDynein Adenosine TriphosphataseDynein AdenosinetriphosphataseElasticityEnsureFamily suidaeGenesGenetic ChangeGenetic defectGenetic mutationGoalsHarvestHigh Resolution Computed TomographyHumanHuman ResourcesImageInfectionInflammationInvestigatorsIowaKartagener SyndromeKartagener TriadKnowledgeLobarLungLung DiseasesLung Respiratory SystemMaintenanceManpowerMeasuresModern ManMonitorMucociliary ClearanceMucociliary TransportMucosaMucosal TissueMucous MembraneMucous body substanceMucusMutationNasal SinusesNasal cavity/ParanasalNasal cavity/Paranasal sinusesNeonatal lungP01 MechanismP01 ProgramPETPET ScanPET imagingPET/CTPET/CT scanPETSCANPETTParanasal SinusesPathogenesisPatientsPersonsPigsPolynesian bronchiectasisPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPreventionPrimary Ciliary DyskinesiasProductionProgram Project GrantProgram Research Project GrantsPulmonary DiseasesPulmonary DisorderRad.-PETResearch PersonnelResearch Program ProjectsResearch ResourcesResearchersResourcesRespiratory FailureRespiratory InfectionsRespiratory Tract InfectionsSamplingSinusStructural ProteinSuidaeSwineTechnologyTherapeuticThickThicknessUniversitiesairway epithelium inflammationairway inflammationanimal carearmautosomebiologicconsultationdata interpretationdata retrievaldata storagedisease of the lungdisorder of the lungexperiencegenome mutationhealth assessmenthigh resolution CTimagingimaging studyimprovedlung disordermodel of animalmucousneonatal pulmonarynewborn lungnewborn pulmonarynovelpersonnelporcinepositron emission computed tomographypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprogramsrespiratory inflammationrespiratory tract inflammationsample collectionspecimen collectionsuccesssuidtool
Description preview
CORE B – ANIMAL MODELS
PROJECT SUMMARY
Primary ciliary dyskinesia (PCD) is an autosomal recessive disease caused by mutations in the genes that
encode cilia structural proteins. Mutations in the DNAI1 gene are common in people with PCD and
characterized by loss of the outer dynein arm (ODA) of the cilia and loss of ciliary beating. Airway…
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