grant
Core A - Establishing the regulatory mechanisms defining cellular function
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 7 Apr 2017Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025ATACATAC sequencingATAC-seqATACseqAlgorithmsAllelesAllelomorphsAssayAssay for Transposase-Accessible Chromatin using sequencingBar CodesBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBody TissuesBrachydanio rerioCell BodyCell DifferentiationCell Differentiation processCell FunctionCell NucleusCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinChromatin StructureClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionCollaborationsCommunitiesConsultationsDNA AlterationDNA Sequence AlterationDNA mutationDanio rerioDataData AnalysesData AnalysisData SetDevelopmentDiseaseDisorderDissectionDistalDysfunctionEducational workshopExperimental DesignsExperimental ModelsFunctional disorderGene Action RegulationGene ActivationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic AlterationGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsHematopoiesisHematopoieticHematopoietic Cellular Control MechanismsHeterogeneityHumanJointsLPTNLineage TracingMapsMeasurementMeasuresMediatingMethodsMiceMice MammalsModelingModern ManMolecular InteractionMurineMusMutationNon-Polyadenylated RNANucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNucleusOutputPhysiopathologyProcessProductionProgenitor CellsProtocolProtocols documentationQuality ControlRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqRegulationRegulatory ElementRegulatory RegionsResearch ResourcesResolutionResourcesRibonucleic AcidRoleRotationSCM-1SCM-1aSCM1SCYC1SamplingScheduleSequence AlterationSeriesSourceSubcellular ProcessTechnologyTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesUniversitiesWorkWorkshopXCL1XCL1 geneZebra DanioZebra FishZebrafishassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbarcodeblood cell formationcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell behaviorcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular behaviorcellular differentiationcellular lineage mappingcellular lineage trackingclonal expansions in the bloodclonal hematopoiesisclones in hematopoietic cellscommunity-centeredcommunity-orientedcomputational pipelinescomputerized data processingconsultationcostcost effectivecost effectivenessdata integrationdata interpretationdata managementdata processingdata sharingdesigndesigningdevelopmentalepigenomicsexperienceexperimentexperimental researchexperimental studyexperimentsgene regulatory networkgenetic regulatory elementgenome mutationgenomic alterationhematopoietic cell cloneshematopoietic differentiationhematopoietic stem cell clonalityhematopoietic tissuehemopoieticinnovateinnovationinnovativeinteractive data visualizationinteractive visualizationinternet resourcemembermultiomicsmultiple omicson-line compendiumon-line resourceonline compendiumonline resourcepanomicspathophysiologyprogenitor biologyprogenitor cell biologyprogramsregeneration biologyregenerative biologyresolutionssample collectionscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespecimen collectionstemstem and progenitor biologystem cell biologystem cellstooltranscription factortranscriptome sequencingtranscriptomic sequencingtranscriptomicsweb interfaceweb resourceweb-based resource
Description preview
Project Summary
The coordinated regulation of chromatin structure, transcription factor binding and RNA
expression is fundamental to cellular differentiation. Methods for measuring different layers of
gene regulation within single cells can be used to determine essential regulators of cell
differentiation and function as sensitive markers of…
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