grant
Core 2: Mammalian Artificial Chromosome (MAC)
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 8 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAnimalsArtificial Human ChromosomesArtificial Mammalian ChromosomesAwardBiologyBudding YeastCancer BiologyCategoriesCell BodyCell CycleCell Division CycleCell divisionCellsCentromereChemicalsChromatinChromatin AssemblyChromatin ModelingChromosome SegregationChromosomesCloningCytoplasmDNADNA DamageDNA InjuryDNA Molecular BiologyDNA RecombinationDNA SequenceDNA cassetteDNA seqDNA sequencingDNAseqDeoxyribonucleic AcidEndomycetalesEngineered GeneEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEssential GenesEventGene Copy NumberGene DosageGenerationsGenesGeneticGenetic RecombinationGenomeGenome InstabilityGenomic InstabilityGenomicsHereditaryHousingHuman GenomeImmunomodulationIndividualInheritedLeadM PhaseMiceMice MammalsMitosisMitosis StageMitoticMitotic ChromosomeMolecularMolecular BiologyMonitorMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsMurineMusNatureOrganoidsOutcomePb elementProcessProteinsRecombinationRegulatory ElementReporterReportingSaccharomycetalesSister ChromatidSiteSystemTechnologyWorkanti-tumor immune responsecell typechemical geneticschromosomal missegregationchromosome divisionchromosome missegregationdesigndesign and constructdesign and constructiondesigningenhancer cassetteepigeneticallyepigenomicsexperimentexperimental researchexperimental studyexperimentsexpression cassettefallsflexibilityflexiblegene cassettegene locusgenetic cassettegenetic informationgenetic locusgenetic payloadgenomic locationgenomic locusheavy metal Pbheavy metal leadhuman whole genomeimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedinnovateinnovationinnovativeintegration cassettemESCmembermicronucleusmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellnext generationpatient responsepatient specific responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprogramspromoter cassettereporter cassetteresistance cassetteresistance to therapyresistant to therapyresponseresponsive patientsegregationselectable cassetteselection cassettestop cassettesynthetic biologytherapeutic resistancetherapy resistanttooltranscription cassettetranscriptional cassettetransgene cassettetreatment resistancetumor
Description preview
The mammalian artificial chromosome (MAC) Core will support the overall Project, which seeks to address the
downstream consequences in cells and animals of DNA damage, the causes and consequences of
chromosome missegregation at cell division, and the mechanisms that drive these processes in tumors. It will
serve as a foundry for MACs that will…
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