grant
Core 2: Ecological Core
Organization H. LEE MOFFITT CANCER CTR & RES INSTLocation TAMPA, UNITED STATESPosted 15 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D3-D structure3-Dimensional3-dimensional structure3D3D structureBehaviorBiological MarkersBionomicsBody TissuesCalibrationCancer TreatmentCancersCatalogingCell BodyCellsClinicalComplexComputer softwareDataDevelopmentDimensionsEcologic SystemsEcological ChangeEcological SystemsEcologyEcosystemEnvironmentFeedbackGenerationsGenotypeHeterogeneityHistologyHistoryImageImmuneImmunesImmunofluorescenceImmunofluorescence ImmunologicIntratumoral heterogeneityInvestigationMaintenanceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMath ModelsMethodsModelingNSCLCNSCLC - Non-Small Cell Lung CancerNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaPatternPulmonary CancerPulmonary malignant NeoplasmRecording of previous eventsResolutionSamplingShelter facilitySliceSoftwareSpeedStaining methodStainsTechniquesTestingThinkingTimeTissuesVisualizationanti-cancer therapybio-markersbiologic markerbiomarkercancer microenvironmentcancer progressioncancer therapycancer-directed therapycomputational pipelinesdata pipelinedevelopmentalheterogeneity in tumorshigh dimensionalityhistological sampleshistological specimenshistology sampleshistology specimenshistoriesimage registrationimage-based methodimagingimaging methodimaging modalityimmune microenvironmentimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedinsightinterestintra-tumoral heterogeneityintratumor heterogeneitylung cancermalignancymathematic modelmathematical modelmathematical modelingmulti-modalitymultimodalitymultiplexed imagingneoplasm progressionneoplasm/cancerneoplastic progressionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachresolutionsresponse to therapyresponse to treatmentsheltershelter housingsheltersspatial and temporalspatial multiomicsspatial omicsspatial temporalspatial tri-omicsspatiotemporaltherapeutic responsetherapy responsethoughtsthree dimensionalthree dimensional structuretissue reconstructiontooltreatment responsetreatment responsivenesstumortumor behaviortumor heterogeneitytumor immune microenvironmenttumor microenvironmenttumor progressiontumor-immune system interactionswhole slide imaging
Description preview
Summary – Ecological Core
Recent advances in spatial ‘omics’ have led to an increased interest in studying and predicting emergent
aggregate behavior and interactions between the tumor and its microenvironment. Tumors are dynamic,
rapidly evolving and undergoing ecological shifts; therefore, the understanding of tumor progression and
response to…
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