grant
Core 2: Analytical Core
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 15 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AffectAgarAnimal ModelAnimal Models and Related StudiesBiologicalBiologyBody TissuesBrain NeoplasiaBrain NeoplasmsBrain TumorsCell BodyCell CommunicationCell Communication and SignalingCell Culture TechniquesCell InteractionCell NucleusCell SignalingCell-to-Cell InteractionCellsClass I GenesClinicalClinical ResearchClinical StudyComplexCore BiopsyCore Needle BiopsyCryosectioningCryoultramicrotomyDataDimensionsDrugsEnsureEquipmentExperimental ModelsExpression ProfilingGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeographyGliaGlial Cell TumorsGlial CellsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHumanHuman ResourcesImageImmuneImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIn VitroIntermediary MetabolismIntracellular Communication and SignalingKnowledgeKolliker's reticulumMHC Class IMHC Class I GenesMalignantMalignant - descriptorManpowerMapsMath ModelsMeasurementMediatingMedicationMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMetadataMethodologyMethodsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMultiomic DataNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuroglial NeoplasmNeuroglial TumorNeuronsNon-neuronal cellNonneuronal cellNucleusPatientsPeptidesPerformancePharmaceutical PreparationsPhosphorylationPopulationPre-Clinical ModelPreclinical ModelsProtein PhosphorylationProteomicsProtocolProtocols documentationQuality ControlRNA SeqRNA sequencingRNAseqReagentReproducibilityResearch ResourcesResearch SpecimenResolutionResourcesSamplingServicesSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSpecimenStudy modelsSystemSystems BiologyTechnologyTherapeuticThickThicknessTimeTissuesTranscript Expression AnalysesTranscript Expression AnalysisTumor Cellaccurate diagnosisanalyze gene expressionbiologicbiological signal transductionbrain tissuecancer microenvironmentcell culturecell culturescell typeclinical relevanceclinically relevantdata managementdata sharingdrug distributiondrug/agentdynamical evolutionforestgene expression analysisgene expression assayglial-derived tumorglioblastoma multiformehuman tissueimage guidanceimage guidedimagingimaging biomarkerimaging markerimaging mass spectrometryimaging-based biological markerimaging-based biomarkerimaging-based markerinformation gatheringmass spectrometric imagingmathematic modelmathematical modelmathematical modelingmeta datametabolism measurementmetabolomicsmetabonomicsmodel of animalmolecular profilemolecular signaturemultiple omic dataneoplastic cellnerve cementneuroglia neoplasmneuroglia tumorneuronalpersonnelphospho-proteomicsphosphoproteomicspre-clinicalpreclinicalprogramsprotein expressionresolutionsresponse to therapyresponse to treatmentsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial integrationspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspongioblastoma multiformetherapeutic responsetherapy responsetissue culturetooltranscriptional profilingtranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment responsetreatment responsivenesstumortumor microenvironmenttumors in the brain
Description preview
ABSTRACT – ANALYTICAL CORE
The Analytical Core will serve as a central resource for the deep systems-level molecular characterization of
biological samples generated by the Projects and from the Biospecimens Core. The primary objective of this
Core is to integrate diverse single cell, bulk, and spatial analytical platforms to define the complex…
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