grant
Core 1: Mathematical Core
Organization H. LEE MOFFITT CANCER CTR & RES INSTLocation TAMPA, UNITED STATESPosted 15 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AnimalsBasic ResearchBasic ScienceBionomicsBloodBlood Reticuloendothelial SystemBlood VesselsBody SystemBody TissuesBone TissueBreastCalibrationCancer CenterCancer TreatmentCancersClinicalClinical DataClinical TrialsComplexComputer ModelsComputerized ModelsConnective TissueDataData CollectionDevelopmentDifferential Algebraic EquationDifferential EquationDiseaseDisorderEcologyEvolutionFacultyGoalsHeterogeneityHistologyHumanHybridsImmuneImmunesIn VitroIntermediary MetabolismLinkLogicLungLung Respiratory SystemMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Soft Tissue NeoplasmMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMapsMathMath ModelsMathematicsMetabolic ProcessesMetabolismMethodsMiceMice MammalsModelingModern ManMolecular Dynamics SimulationMurineMusNSCLCNSCLC - Non-Small Cell Lung CancerNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaOncologyOncology CancerOrgan SystemPathway interactionsPatientsPhenotypePlayPreclinical TestingPreclinical dataProcessProstateProstate GlandProstatic GlandPulmonary CancerPulmonary malignant NeoplasmRegimenResolutionSarcomaScienceServicesSkinStromal NeoplasmStromal TumorTestingTissuesTumor BurdenTumor LoadUncertaintyWorkanti-cancer therapybrain tissuecancer cellcancer microenvironmentcancer therapycancer typecancer-directed therapycell typeclinical investigationcohortcomputational modelingcomputational modelscomputer based modelscomputerized modelingdata integrationdevelopmentaldoubtdynamic systemdynamical systemflexibilityflexiblein vivoinnovateinnovationinnovativeinsightlung cancermalignancymalignant soft tissue tumormathematic modelmathematical modelmathematical modelingmembermolecular dynamicsmolecular scalemultidisciplinaryneoplasm/cancernovelpathwayphase 1 trialphase I trialpre-clinicalpre-clinical testingpreclinicalpreclinical findingspreclinical informationprogramsresolutionsresponse to therapyresponse to treatmenttheoriestherapeutic responsetherapy optimizationtherapy responsetooltreatment optimizationtreatment responsetreatment responsivenesstreatment strategytumortumor growthtumor initiationtumor microenvironmentvascularvirtualvirtual patient
Description preview
Summary – Mathematical Modeling Core
Understanding the changes in tumor ecology (“∆-Ecology”) that occur during tumor initiation, progression, and
therapy requires careful study of a complex dynamical system involving multiple scales – from molecular to
cellular to tissue to systemic. An important tool in this study is the use of mathematical…
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