grant
Core 1: Biological Correlation and Analysis Core
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Jul 2007Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAfter CareAfter-TreatmentAftercareAnimalsAnti-Cancer AgentsAnti-cancer natural productsAnti-tumor Natural ProductsAntibody-drug conjugatesAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAssayAutophagocytosisBinding ProteinsBioassayBioinformaticsBioinformatics coreBioinformatics research coreBioinformatics resource coreBiologicalBiological AssayBiological TestingBiometricsBiometryBiostatisticsBiotinylationBlue-Green AlgaeBlue-Green BacteriaCRISPRCRISPR/Cas systemCancer DrugCancer ModelCancer TreatmentCancer cell lineCancerModelCancersCardiac GlycosidesCardiotonic SteroidsCell BodyCell Communication and SignalingCell LineCell SignalingCell modelCellLineCellsCellular modelChemical StructureChemistryChemoresistanceClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCombined Modality TherapyComplex ExtractsComplex MixturesConjugated CarrierCrude ExtractsCyanobacteriumCyanophyceaeCyanophytaDataDevelopmentDoseDrug KineticsEnsureEvaluationFeedsFibroblastsFormulationGeneticGoalsHeterograftHeterologous TransplantationHumanImageImmobilizationImmune systemIn VitroIncubatedIntracellular Communication and SignalingLigand Binding ProteinLigand Binding Protein GeneLytotoxicityMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaterials TestingMedicinal ChemistryMiceMice MammalsModelingModern ManMolecularMolecular TargetMultimodal TherapyMultimodal TreatmentMurineMusNatural CompoundNatural ProductsNatural SourceNatural anti-cancer agentsNatural antineoplastic agentsNatural chemotherapeutic agentsNatural chemotherapeutic productsNatural product anti-neoplasticsNeoplastic Disease Chemotherapeutic AgentsOvary CancerP01 MechanismP01 ProgramPathway interactionsPharmaceutic ChemistryPharmaceutical ChemistryPharmacokineticsPlantsPreclinical TestingProgram Project GrantProgram Research Project GrantsPropertyProtein BindingProtein OverexpressionProteinsProteomicsRNA SeqRNA sequencingRNAseqResearch Program ProjectsRoleRouteSamplingScreening for cancerSignal TransductionSignal Transduction SystemsSignalingSolventsSpecificityStrains Cell LinesStructureSystemTestingTumor BurdenTumor Cell LineTumor LoadTumor-Specific Treatment AgentsWorkXenograftXenograft procedureXenotransplantationanaloganti-canceranti-cancer druganti-cancer therapyautophagybiologicbiological signal transductionbound proteincancer cellcancer therapycancer-directed therapycancers that are rarechemoresistantchemotherapy resistancechemotherapy resistantcombination therapycombined modality treatmentcombined treatmentcomplex extractcrosslinkcultured cell linecytotoxiccytotoxicitydesigndesigningdevelopmentaldrug candidateearly cancer detectionefficacy studyfungusimagingimprovedin vivoinhibitorinnovateinnovationinnovativeknock-downknockdownmalignancymulti-modal therapymulti-modal treatmentnanocarriernanovesselnaturally occurring compoundnaturally occurring productneoplasm/cancernovelorthopedic freezingovarian cancerpathwaypost treatmentpre-clinical testingprogramsrare cancerrare malignancyrare tumorresponserocaglamidescaffoldscaffoldingscreening cancer patientssocial rolethree dimensionaltranscriptome sequencingtranscriptomic sequencingtumorxeno-transplantxeno-transplantation
Description preview
PROJECT SUMMARY – BIOLOGICAL CORRELATION AND ANALYSIS CORE (CORE 1)
The Biological Correlation and Analysis Core (Core 1) will focus on the biological evaluation of anticancer
natural products that are identified from complex extracts, and after subsequent isolation, confirmed to be the
active constituent. This strategy, called bioassay-guided…
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