grant
Core-003
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 10 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoV3-D3-Dimensional3DAffectAstrocytesAstrocytusAstrogliaBasal CellBiologyBloodBlood - brain barrier anatomyBlood Coagulation DisordersBlood NeutrophilBlood PlateletsBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemBlood SampleBlood monocyteBlood specimenBlood-Brain BarrierBrainBrain Nervous SystemCASP11CASP4CASP4 geneCOVID disease severityCOVID infected patientCOVID patientCOVID positive patientCOVID severityCOVID-19COVID-19 disease severityCOVID-19 infected patientCOVID-19 infectionCOVID-19 pathogenesisCOVID-19 patientCOVID-19 positive patientCOVID-19 severityCOVID-19 therapyCOVID-19 treatmentCOVID-19 virusCOVID-19 virus infectionCOVID19 disease severityCOVID19 infectionCOVID19 pathogenesisCOVID19 patientCOVID19 positive patientCOVID19 severityCOVID19 virusCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCV-19CadaverCas nuclease technologyCaspaseCaspase GeneCell BodyCell Culture TechniquesCell IsolationCell LineCell SegregationCell SeparationCell Separation TechnologyCell-Death ProteaseCellLineCellsChemotactic CytokinesClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoV-2CoV2Coagulation DisorderCoagulopathyComplementComplement ProteinsCoronavirus Infectious Disease 2019Cysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCystic FibrosisDataDerivationDerivation procedureDevelopmentDevelopment and ResearchDrugsEncephalonEndothelial CellsEndotheliumEpithelial CellsFoundationsFundingGene ModifiedGoalsHealthHeartHemato-Encephalic BarrierHomologous Chemotactic CytokinesHortega cellHumanICE and CED3 Homolog 2ICE-like proteaseICH-2ImmuneImmunesIndividualInflammasomeInflammationInjuryIntercrinesInvestigatorsKO miceKnock-out MiceKnockout MiceKnowledgeLeadLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019LungLung ParenchymaLung Respiratory SystemLung TissueLymphatic cellLymphocyteLymphocyticMacrophageMaintenanceMarrow NeutrophilMarrow monocyteMarrow plateletMediatingMedicationMiceMice MammalsMicrogliaModern ManMouse Homolog of Caspase 11MucinsMucoviscidosisMucus GlycoproteinMurineMusMφNerve CellsNerve UnitNeural CellNeurocyteNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurological ManifestationsNeurological Signs and SymptomsNeuronsNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Polyadenylated RNANull MouseOrganPathologyPathway interactionsPatientsPb elementPersonsPharmaceutical PreparationsPlateletsPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProgram DevelopmentQuantitative RTPCRQuantitative Reverse Transcriptase PCRR & DR&DRNARNA Gene ProductsReportingResearch PersonnelResearch ResourcesResearchersResourcesRespiratory EpitheliumRibonucleic AcidRistocetin CofactorRistocetin-Willebrand FactorRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 disease severitySARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV-2 severitySARS-CoV-2 therapySARS-CoV-2 treatmentSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SIS cytokinesSamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2SiteStrains Cell LinesStructure of parenchyma of lungStructure of respiratory epitheliumSymptomsThrombocytesThrombosisTranslatingViral DiseasesVirulenceVirusVirus DiseasesWuhan coronavirusadaptive immunityairway epitheliumastrocytic gliableeding disorderbloodbrain barrierbrain cellbrain fogbrain tissuebronchial epitheliumcadavericcadaverscell culturecell culturescell sortingcell typechemoattractant cytokinechemokinechronic COVIDchronic COVID-19chronic novel coronavirus disease 2019clotting disordercomplementationcoronavirus disease 2019coronavirus disease 2019 disease severitycoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 pathogenesiscoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 severitycoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease severitycoronavirus disease-19coronavirus disease-19 pathogenesiscoronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcultured cell linecystein proteasecystein proteinasecysteine endopeptidasecytokinecytokine release syndromecytokine stormdevelopmentaldrug/agentexperimentexperimental researchexperimental studyexperimentsgene modificationgenetically modifiedgitter cellhCoV19heavy metal Pbheavy metal leadinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2injurieslong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019long-term sequelaelymph cellmesogliamicroglial cellmicrogliocytemonocytemouse modelmurine modelnCoV2neural manifestationneuronalneutrophilnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpandemicpandemic diseasepathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2perivascular glial cellpersistent COVID-19post COVID syndromepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19preventpreventingprogramsprolonged COVID-19 symptomspulmonaryqRTPCRresearch and developmentrespiratory tract epitheliumsevere acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere acute respiratory syndrome coronavirus 2 severitysevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentsocial rolethree dimensionalthrombotic diseasethrombotic disordertranscriptomicstreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2viral infectionvirus infectionvirus-induced diseasevon Willebrand Factorvon Willebrand Protein
Description preview
CORE 4 - SUMMARY
COVID-19 remains a worldwide health threat. While some people recover quickly and have mild/no symptoms,
at least one third develop long-term symptoms referred to as Long-COVID. In order to identify new therapeutic
targets this Program will decipher the role of specific pathways and identify the cell-types that control…
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