grant
Core-002
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 10 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAffectAnesthesiaAnesthesia proceduresAnimal ModelAnimal Models and Related StudiesAnimalsAssayB.1.1.529B.1.617.2BSL-3 facilityBSL3 facilityBioassayBiologic SciencesBiologicalBiological AssayBiological SciencesBioscienceBiostatistics CoreBloodBlood Coagulation DisordersBlood Reticuloendothelial SystemBody Weight ChangesBrainBrain Nervous SystemBreedingCOVID disease severityCOVID severityCOVID-19COVID-19 disease severityCOVID-19 infectionCOVID-19 severityCOVID-19 therapeuticsCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID19 disease severityCOVID19 infectionCOVID19 severityCOVID19 virusCV-19CaspaseCaspase GeneCaspase InhibitorCell BodyCell-Death ProteaseCellsCoV-2CoV2Coagulation DisorderCoagulopathyCollaborationsComplementComplement ProteinsConchae NasalesCoronavirus Infectious Disease 2019CricetinaeCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesCytokines and Inflammatory ResponseDelta variantDetectionDevelopmentEC 2.1.1ELISAEncephalonEnsureEnzyme-Linked Immunosorbent AssayEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEuthanasiaGEM modelGEMM modelGenetically Engineered MouseGenomeGenotypeGoalsGolden HamstersGolden Syrian HamstersHamstersHamsters MammalsHealthHeartHistologyHumanICE-like proteaseImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn VitroInfectionInflammasomeInflammatoryInflammatory Response PathwayInnate ImmunityInvestigatorsIsofluraneKO miceKidneyKidney Urinary SystemKnock-out MiceKnockout MiceLeadLife SciencesLiverLoxP-flanked alleleLungLung Respiratory SystemMediatingMercy KillingMesocricetus auratusMethyltransferaseMiceMice MammalsModelingModern ManModificationMolecularMurineMusNasalNasal Passages NoseNasal turbinate bone structureNative ImmunityNatural ImmunityNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityNoseNull MouseOhioOmicron variantOrganP01 MechanismP01 ProgramPathologyPb elementPlaque AssayProceduresProgram Project GrantProgram Research Project GrantsQualifyingR-Series Research ProjectsR01 MechanismR01 ProgramRNARNA Gene ProductsReagentRecombinantsReproducibilityResearch GrantsResearch PersonnelResearch Program ProjectsResearch Project GrantsResearch ProjectsResearchersRespiratory System, Nose, Nasal PassagesRibonucleic AcidRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 B.1.1.529SARS-CoV-2 B.1.617.2SARS-CoV-2 deltaSARS-CoV-2 disease severitySARS-CoV-2 infectionSARS-CoV-2 omicronSARS-CoV-2 omicron variantSARS-CoV-2 severitySARS-CoV-2 therapeuticsSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 therapeuticsSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2ServicesSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 therapeuticsSevere acute respiratory syndrome related corona virus 2StandardizationSymptomsSyrian HamstersTestingTherapeutic AgentsTherapeutic EffectTissue ExtractsTitrationsTransgenic OrganismsTurbinatesUniversitiesVeterinariansVeterinary MedicineViral BurdenViral DiseasesViral GenomeViral LoadViral Load resultVirusVirus DiseasesWeight ChangeWuhan coronavirusadaptive immunityafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionanimal tissuebiologicbiosafety level 3 facilitybleeding disorderbronchial epitheliumclotting disordercollegecollegiatecomplementationcoronavirus disease 2019coronavirus disease 2019 disease severitycoronavirus disease 2019 infectioncoronavirus disease 2019 severitycoronavirus disease 2019 therapeuticscoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease severitycoronavirus disease-19coronavirus disease-19 viruscoronavirus infectious disease-19cystein proteasecystein proteinasecysteine endopeptidasecytokinedesigndesigningdevelopmentalefficacy testingenzyme linked immunoassayepigeneticallyexpectationexperimentexperimental researchexperimental studyexperimentsfloxedfloxed allelefollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectiongenetically engineered mouse modelgenetically engineered murine modelhCoV19heavy metal Pbheavy metal leadhepatic body systemhepatic organ systemhuman diseaseimprovedin vivoinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2instrumentationlong-term sequelaemethylasemodel of animalmouse genomenCoV2new drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetomicron variant of COVID-19omicron variant of SARS-CoV-2post SARS-CoV-2 infectionpreventpreventingprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionprogramsquality assurancerenalrespiratory virussevere acute respiratory syndrome coronavirus 2 B.1.1.529severe acute respiratory syndrome coronavirus 2 B.1.617.2severe acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 severitysevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssocial roletherapeutics against COVID-19therapeutics against SARS-CoV-2therapeutics against SARS-coronavirus-2therapeutics against Severe acute respiratory syndrome coronavirus 2therapeutics against coronavirus disease 2019therapeutics for novel coronavirustransgenictransmethylasevariants of concernviral infectionvirologyvirus genomevirus infectionvirus-induced disease
Description preview
Biological Reagents and Infection Core
Core 3 - ABSTRACT
The overall goals of this Program Project Grant (P01) are to define the functional and molecular roles of caspase- 4/11 (CASP4/11) and RNA epigenetic modifications in SARS-CoV-2 pathobiology in the lung, brain, blood, and heart, to characterize the roles of CASP4/11 and RNA epigenetic…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click