grant
Controlling Neuropilin-2 Signaling to Improve Lymphatic Function
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 5 Jun 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years old7B4 Antigen7B4 protein7S Gamma GlobulinAKTAccelerationAdipocytesAdipose CellAdultAdult HumanAilmentary SystemAkt proteinAlimentary CanalAlimentary SystemAnimal ModelAnimal Models and Related StudiesAntibodiesAssayBackBindingBinding Site DomainBioassayBiochemicalBiological AssayBiologyBlood CirculationBloodstreamBody WeightBody Weight decreasedCD144 AntigenCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell SignalingCellsCellular Immune FunctionChronic DiseaseChronic IllnessChyleClosure by LigationComplexDataDepositDepositionDietary FatsDigestive SystemDigestive TractDiseaseDisorderDisparateDorsumDrainageDrainage procedureDrugsDuctDuct (organ) structureDysfunctionEpidemicExclusionFLT4 ProteinFMS-Related Tyrosine Kinase 4Fat CellsFatsFatty acid glycerol estersFlt-4FosteringFunctional disorderGI TractGastrointestinal Body SystemGastrointestinal Organ SystemGastrointestinal TractGastrointestinal tract structureGenomicsHealthHeart VascularHigh Fat DietHumanIgGImmuneImmune SurveillanceImmunesImmunoglobulin GImmunologic SurveillanceImmunosurveillanceInfectionInflammationInflammatoryInjuryIntestinalIntestinesIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLeadLigand Binding DomainLigandsLigationLipid TraffickingLipidsLipocytesLiquid substanceLymph SystemLymphangiogenesesLymphangiogenesisLymphangiogramLymphangiographyLymphaticLymphatic AbnormalitiesLymphatic CapillariesLymphatic DiseasesLymphatic Endothelial CellsLymphatic NetworkLymphatic SystemLymphatic System Reticuloendothelial SystemLymphatic anomaliesLymphatic defectsLymphatic functionLymphedemaManuscriptsMature LipocyteMature fat cellMediatingMedicationMembraneMetabolicMetabolic DiseasesMetabolic DisorderMetabolic syndromeMiceMice MammalsMissionModalityModern ManMolecularMolecular InteractionMurineMusNRP2 ProteinNational Institutes of HealthNeuropilin-2Npn-2 ProteinNull MouseObesityPathway interactionsPb elementPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePhysiopathologyPre-Clinical ModelPreclinical ModelsProtein Kinase BProteinsProto-Oncogene Proteins c-aktR-Series Research ProjectsR01 MechanismR01 ProgramRAC-PK proteinReceptor ProteinReceptor SignalingRecyclingResearchResearch GrantsResearch Project GrantsResearch ProjectsResolutionRoleSEMA3FSEMA3F geneSEMAKSema4SemaphorinsSignal InductionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSmall IntestinesSwellingTestingTherapeuticThesaurismosisTransgenic MiceTranslatingTyrosine-Protein Kinase Receptor FLT4United StatesUnited States National Institutes of HealthVE-CadherinVEGFAVEGFA geneVEGFCVEGFC geneVEGFR-3VEGFR3VRP GeneVascular Endothelial CadherinVascular Endothelial Cadherin 1Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor C GeneVascular Endothelial Growth Factor Receptor-3Vascular SystemVasculotropinWeightWeight GainWeight IncreaseWeight LossWeight ReductionWild Type Mouseabsorptionadiposityadulthoodalimentary tractbasal bodybiological signal transductionbody weight gainbody weight increasebody weight lossbowelbowel inflammationc-akt proteincadherin 5chronic disordercirculatory systemco-morbidco-morbiditycombatcomorbiditycompare to controlcomparison controlconfocal imagingcorpulencediet-associated obesitydiet-induced obesitydiet-related obesitydietary lipiddigestive canaldrug/agenteffective therapyeffective treatmentfluidgastrointestinal systemgut inflammationheavy metal Pbheavy metal leadimmune functionimprovedin vivoinflamed bowelinflamed gutinflamed intestineinjuriesinnovateinnovationinnovativeintestinal inflammationkinetosomelacteallipid transportliquidlymph capillarieslymph channellymph edemalymph vessellymphatic channellymphatic disorderlymphatic drainagelymphatic edemalymphatic malformationslymphatic vesselmembrane structuremesenteric lymphaticsmetabolism disordermodel of animalneonatal miceneutralizing antibodynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyobesity preventionpathophysiologypathwaypharmaceuticalpostnatalpreventprevent obesitypreventingproto-oncogene protein RACproto-oncogene protein aktrac protein kinasereceptorrelated to A and C-proteinresolutionsresponserestraintscRNA sequencingscRNA-seqsecondary lymphedemasemaphorin IVsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall bowelsocial roletherapeutic evaluationtherapeutic testingtooltraffickinguptakeweightswildtype mousewt gainwt-loss
Description preview
Lymphatics are vital for fluid recycling, immune surveillance, and lipid uptake. Abnormal lymphatics lead to
lymphedema, metabolic changes, inflammation, and infections and contribute to the pathophysiology of many
chronic illnesses. In response to the NIH mission (NOT-HL-23-099) promoting research on the biology of the
lymphatic system to advance…
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