grant
Controlling metabolic fluxes for better human haematopoietic stem cell function
Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
Description preview
Hematopoietic stem cells (HSCs) ex vivo culture is a fundamental step for HSC-based Gene Therapy (GT), the only curative treatment for more than 10 distinct monogenic diseases worldwide. However, a major clinical challenge for HSC GT arises from the loss of HSC function during ex vivo culture, posing a high risk of delayed or failed blood recovery…
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