grant
Controlling FKBP51 for the treatment of PTSD
Organization JAMES A. HALEY VA MEDICAL CENTERLocation TAMPA, UNITED STATESPosted 1 Oct 2019Deadline 30 Sept 2028
VANIHUS FederalResearch GrantFY2025AffectAffective DisordersAnti-sense TechnologyAntisense AgentAntisense OligonucleotidesAntisense TechnologyArmed Forces PersonnelBehaviorBiologyBrainBrain Nervous SystemCausalityComplexDataDiseaseDisinhibitionDisorderDorsalEncephalonEquilibriumEtiologyExposure toFK506 binding protein 5FKBP51FKBP54FearFrightGenesGoalsHPA axisHomeHumanIn VitroIndividualKO miceKnock-out MiceKnockout MiceKnowledgeLateralLeadLearningMeasuresMediatingMental DepressionMental disordersMental health disordersMiceMice MammalsMilitaryMilitary PersonnelModern ManMolecularMood DisordersMurineMusNull MouseOligoOligonucleotidesOutcomePTSDPatientsPb elementPhenotypePost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPredispositionPrefrontal CortexProteinsPsychiatric DiseasePsychiatric DisorderReportingResistanceRiskRoleSingle Base PolymorphismSingle Nucleotide PolymorphismSoldierSpecificityStressSusceptibilitySymptomsSystemTestingTherapeuticTranslationsTraumaVeteransWorkantisense oligobalancebalance functionbiological adaptation to stresscausationdepressiondisease causationfrontal cortexfrontal lobeheavy metal Pbheavy metal leadhomeshypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisimprovedin vivoinsightknock-downknockdownmental illnessmilitary populationmouse modelmurine modelneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatrynew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approacholigosoverexpressoverexpressionpost-trauma stress disorderposttrauma stress disorderpreventpreventingpsychiatric illnesspsychologicpsychologicalpsychological disorderreaction; crisisresilienceresilientresilient to stressresistantsingle nucleotide variantsocial rolestress resiliencestress resiliencystress responsestress; reactionstressortacrolimus binding protein 5therapeutic agent developmenttherapeutic developmenttissue woundtooltranslationtraumatic neurosiswoundwoundingwounds
Description preview
Though physical wounds have been reduced in recent military conflicts, many Soldiers return
home with psychological wounds that manifest as post-traumatic stress disorder (PTSD), depression,
and other neuropsychiatric disorders. Some Veterans may be predisposed to these disorders due to
the presence of the common rs1360780 single nucleotide…
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