grant
Controlling epilepsy symptoms with precisely timed inhibition and circuit editing
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 5 Mar 2026Deadline 4 Mar 2029
NIHUS FederalResearch GrantFY202621+ years oldAcuteAdultAdult HumanAmmon HornAnimal ModelAnimal Models and Related StudiesBehaviorBehavioral AssayCell BodyCellsChronicCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommunicating JunctionComplexConnector NeuronConnexinsCornu AmmonisDNA TherapyDentate FasciaDiseaseDisorderDisturbance in cognitionDysfunctionElectrophysiologyElectrophysiology (science)EngineeringEntorhinal AreaEnvironmentEpilepsyEpileptic SeizuresEpilepticsFascia DentataFellowshipFire - disastersFiresFunctional disorderGap Junction ProteinsGap JunctionsGene Transfer ClinicalGeneralized seizuresGenetic InterventionGoalsGrantGyrus DentatusHippocampusImpaired cognitionImpairmentIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInvestigatorsLearningLinkLow-resistance JunctionMedialMediatingMediatorMemoryMemory DeficitMemory impairmentMethodsMiceMice MammalsMurineMusNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurophysiology / ElectrophysiologyNexus JunctionOrganism-Level ProcessOrganismal ProcessParvalbuminsPathologyPatientsPerformancePhasePhysiologic ProcessesPhysiological ProcessesPhysiologyPhysiopathologyPopulationPostdocPostdoctoral FellowPredispositionR-Series Research ProjectsR01 MechanismR01 ProgramRecurrenceRecurrentReportingResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch TrainingResearchersRoleRunningSeizure DisorderSeizuresSusceptibilitySymptomsSystemTechniquesTemporal LobeTemporal Lobe EpilepsyTestingTimeTrainingWorkadulthoodbehavioral impairmentcareercell typeco-morbidco-morbiditycognitive defectscognitive dysfunctioncognitive losscognitive processcomorbiditydentate gyrusdesigndesigningelectrophysiologicalentorhinal cortexepilepsiaepilepsy participantepilepsy patientepilepsy subjectepilepsy volunteerepileptic patientepileptic subjectepileptogenicexperienceexperimentexperimental researchexperimental studyexperimentsfiregene repair therapygene therapygene-based therapygenetic therapygenomic therapyhippocampalimpaired behaviorimprovedmemory dysfunctionmemory processmemory processingmodel of animalmouse modelmurine modelneurological diseaseneuronalneuronal circuitneuronal circuitrynoveloptogeneticspathophysiologypatients with epilepsypost-docpost-doctoralpost-doctoral traineeresearch associatessocial rolestellate celltemporal cortextooltraining projecttranslational opportunitiestranslational potential
Description preview
PROJECT SUMMARY/ABSTRACT
Temporal lobe epilepsy (TLE) is a complex neurological disorder that is characterized by spontaneous,
reoccurring seizures and often presents with debilitating cognitive comorbidities including learning and memory
deficits. Current treatments for TLE are ineffective at managing cognitive comorbidities and often exacerbate…
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