grant
Controlling Bacterial Amyloid Formation and the Influence of Curli Subunits on Pathogenic Alpha-synuclein Aggregation
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Apr 2016Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20252(lH)-pyridinone2-hydroxypyridine2-pyridinone2-pyridoneAccelerationAdoptedAmyloidAmyloid A4 Protein PrecursorAmyloid Protein PrecursorAmyloid SubstanceAmyloid beta-Protein PrecursorAmyloid fibersAmyloid β-Protein PrecursorAntibiotic AgentsAntibiotic DrugsAntibioticsAntimicrobial ResistanceAssayAttenuatedBacteriaBacteriophagesBindingBioassayBiochemicalBiogenesisBiological AssayBiological FunctionBiological ProcessBrainBrain Nervous SystemCell BodyCell DifferentiationCell Differentiation processCell ProtectionCell surfaceCell-Extracellular MatrixCellsChaperoneChemicalsColiform BacilliCytoprotectionDegenerative Neurologic DisordersDevelopmentE coliE. coliECMEncephalonEnsureEnteric BacteriaEnterobacteriaEnterobacteriaceaeEscherichia coliExpression SignatureExtracellular MatrixFiberFluorescence Light MicroscopyFluorescence MicroscopyGI microbiotaGastrointestinal microbiotaGene Expression ProfileGene TranscriptionGeneHomologGenesGeneticGenetic TranscriptionGenetics-MutagenesisGenomeGram-Negative BacteriaGrantHomologHomologous GeneHomologueHumanIn VitroKnowledgeLearningLifeLinkLocationLytotoxicityMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembraneMiceMice MammalsMicrobial BiofilmsMinorMiscellaneous AntibioticModelingModern ManMolecular ChaperonesMolecular InteractionMurineMusMutagenesisMutagenesis Molecular BiologyNAC precursorNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationOrigin of LifeOutcomePARK1 proteinPARK4 proteinParalysis AgitansParkinsonParkinson DiseasePathogenesisPathogenicityPathway interactionsPatternPeriplasmic SpacePhagesPhasePolymersPopulationPrimary ParkinsonismProtein ExportProtein Export PathwayProtein SubunitsProteinsProteomicsRNA ExpressionResolutionRoleSNCASNCA proteinSpecificitySurfaceSymptomsSystemTestingTherapeuticToxic effectToxicitiesTranscriptionUPECUrinary tract infectionUrinary tract infectious diseaseUropathogenic E coliUropathogenic E. coliUropathogenic Escherichia coliVirulenceWorka-syna-synucleinalpha synucleinalpha synuclein genealphaSP22amyloid assemblyamyloid formationamyloid precursor proteinanti-microbial resistantasynattenuateattenuatesbacteria in the gutbacterial virusbiofilmbiophysical approachesbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical methodologybiophysical methodsbiophysical parametersbiophysical propertiesbiophysical techniquescellular differentiationcytoprotectivecytotoxiccytotoxicitydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalenteric microbial communityenteric microbiotaenvironmental stressesenvironmental stressorexperimentexperimental researchexperimental studyexperimentsextracellulargastrointestinal microbial floragene expression patterngene expression signaturegut bacteriagut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahost colonizationhuman diseaseinhibitorintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloraion mobilitymembrane structuremicrobialmouse modelmurine modelneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon A-beta component of AD amyloidnon A4 component of amyloid precursornovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwayperiplasmpolymerpolymericpolymerizationpreventpreventingprotein foldingreconstitutereconstitutionresistance to anti-microbialresistant to antimicrobialresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle moleculesingle-cell RNA sequencingsmall moleculesocial rolesuperresolution microscopysynucleintherapeutic targettime usetranscriptional profiletranscriptional signaturetranscriptomicsurinary infectionα synuclein geneα-synα-synuclein
Description preview
Escherichia coli (E.coli) and other enteric bacteria are a major cause of human diseases. Biofilm formation
contributes greatly to bacterial persistence and antimicrobial resistance in the host. A striking aspect of biofilms
is the “division of labor” that drives unique subpopulation development. Many Enterobacteriaceae, such as E.
coli, produce…
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