grant
Control of cell cycle commitment by APC-C-Cdh1
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AneuploidAneuploidyCDK4CDK4 geneCancer TreatmentCancersCell BodyCell Communication and SignalingCell CycleCell Cycle ControlCell Cycle ProgressionCell Cycle RegulationCell Division CycleCell Division Kinase 4Cell FractionCell SignalingCell divisionCellsCyclin-Dependent Kinase 4Cyclin-Dependent KinasesCyclin-Dependent Protein KinasesDNA ContentDNA DamageDNA IndexDNA InjuryDNA PloidyDrug usageDrugsEnsureFirst Gap PhaseG1 PhaseG1 periodG2 PhaseG2 periodGap Phase 1Gap Phase 2Genome InstabilityGenomic InstabilityGoalsIntracellular Communication and SignalingMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMedicationMitogensMolecularPSK-J3Pharmaceutical PreparationsPhasePloidiesS PeriodS phaseSecond Gap PhaseSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSourceStressSynthesis PeriodSynthesis PhaseWorkanti-cancer therapybiological signal transductioncancer therapycancer typecancer-directed therapycdk Proteinschromosome complementclinical relevanceclinically relevantdrug usedrug/agentgenome integritygenomic integrityimprovedinhibitorlive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancyneoplasm/cancerprematureprematuritypreventpreventing
Description preview
Cells were long thought to irreversibly commit to a round of cell division at a specific point in G1 phase, thus ensuring that cells maintain genome integrity. However, our work over the past several years has demonstrated a number of different conditions that cause cells to de-commit from the cell cycle in later phases, including S and G2 phase.…
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