grant
Contribution of Small Airways to Mucociliary Transport Dysfunction
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Apr 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AffectAirAirway DiseaseAlgorithmic AnalysesAlgorithmic AnalysisAlveolarAnalyses of AlgorithmsAnalysis of AlgorithmsAnimal ModelAnimal Models and Related StudiesAnionsAssayAsthmaBackBioassayBiologic ModelsBiological AssayBiological ModelsBirthBloodBlood Reticuloendothelial SystemBronchial AsthmaCF PreschoolersCF airwayCFTRCFTR ProteinCOPDCell Communication and SignalingCell SignalingCharacteristicsChildren with CFChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseCiliaClinicalCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDataDefectDevelopmentDistalDorsumDuctDuct (organ) structureDysfunctionEarly InterventionElasticityEnvironmentEventFamily suidaeFibrosing AlveolitisFunctional disorderGasesGene TranscriptionGenetic TranscriptionGlandGoalsHost Defense MechanismImpairmentIndividualInhalationInhalingIntracellular Communication and SignalingInvadedKartagener SyndromeKartagener TriadLiquid substanceLocomotionLungLung DiseasesLung Respiratory SystemMeasuresMediatingMicrobeModel SystemMotionMovementMucociliary ClearanceMucociliary TransportMucolytic AgentsMucolyticsMucous body substanceMucoviscidosisMucusO elementO2 elementOrganismOutcomeOutcome StudyOxygenPETPET ScanPET imagingPET/CTPET/CT scanPETSCANPETTParticle SizeParturitionPathogenesisPeriodicalsPhysiopathologyPigsPolynesian bronchiectasisPositronPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Ciliary DyskinesiasProcessPropertyPulmonary DiseasesPulmonary DisorderRNA ExpressionRad.-PETResearchRespiratory EpitheliumRoleSignal TransductionSignal Transduction SystemsSignalingSliceStructure of respiratory epitheliumSubmucosaSuidaeSurfaceSwineSystemTCEPTechniquesTestingTherapeuticTimeTracheaTrachea ProperTranscriptionTransgenic AnimalsTubeairway epitheliumbiological signal transductionbody movementchildren with cystic fibrosischronic obstructive pulmonary disordercystic fibrosis airwaycystic fibrosis preschoolerscystic fibrosis transmembrane regulatordevelopmentaldiffuse interstitial pulmonary fibrosisdigitaldisease modeldisease of the lungdisorder modeldisorder of the lungfluididiopathic pulmonary fibrosisin vivoinnovateinnovationinnovativeliquidliving systemlung disordermodel of animalmodel organismmucousnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachparticlepathogenpathophysiologypediatric cystic fibrosisperiodicperiodicalporcinepositron emission computed tomographypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreferencepreventpreventingradiolabelradiolabelsradiotracerrespiratory tract epitheliumsocial rolespatial and temporalspatial temporalspatiotemporalsuccesssuidtemporal measurementtemporal resolutiontime measurementtris(2-carboxyethyl)phosphineviscoelasticitywindpipe
Description preview
PROJECT SUMMARY
The airway system is composed of asymmetric dichotomously branching tubes lined with respiratory epithelium
that form a barrier at the interface with the environment. The airways carry a simple function of conducting
oxygen rich air to the alveolar space where gas exchange with the blood occur. By doing that, pathogens and…
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