grant
Contribution of Nutrient Delivery Rate to Gut-Brain Axis Signaling in Obesity and Bariatric Surgery
Organization LSU PENNINGTON BIOMEDICAL RESEARCH CTRLocation BATON ROUGE, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AffectAmino AcidsAnatomic SitesAnatomic structuresAnatomyAnti-Obesity AgentsAnti-Obesity DrugsAutomobile DrivingBariatricsBehaviorBody Weight decreasedBrainBrain Nervous SystemBrain imagingBrain regionCCKCNS Nervous SystemCaloric IntakeCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous SystemCholecystokininChronicClinicalCouplingD-GlucoseDataDetectionDevelopment PlansDextroseDuodenumEatingEncephalonEndocrineEnergy IntakeEnteralEnteral FeedingEntericEnvironmentFeeding behaviorsFoodFood IntakeFood PreferencesFunctional MRIFunctional Magnetic Resonance ImagingFutureGLP-1GangliaGastrectomyGastric BypassGastrointestinal MotilityGastrostomy tubeGlp-1GlucoseGoalsGustationHumanInfusionInfusion proceduresIngestive BehaviorIntestinalIntestinal MucosaIntestinesIntracellular Communication and SignalingIsocaloricK-AwardsK-Series Research Career ProgramsKnowledgeLiquid substanceMeasurementMeasuresMediatingMentorsModelingModern ManNerve Impulse TransmissionNerve TransmissionNeural GanglionNeuraxisNeuronal TransmissionNutrientNutrient-dense foodNutritious-dense foodObesityObesity EpidemicOperative ProceduresOperative Surgical ProceduresOralPancreozyminPathway interactionsPatientsPeptidesPerceptionPeripheralPhysiologyPositionPositioning AttributePostoperativePostoperative PeriodPre-Clinical ModelPreclinical ModelsProcessResearchResearch Career ProgramRewardsRodentRodentiaRodents MammalsSatiationSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSurgicalSurgical InterventionsSurgical ProcedureTasteTaste PerceptionTaste preferencesTestingTracerTrainingTranslatingUropancreozyminWeight LossWeight ReductionWorkabsorptionadiposityaminoacidanaloganti-obesity compoundsanti-obesity medicationsanti-obesity therapeuticsaxon signalingaxon-glial signalingaxonal signalingbariatric surgerybiological signal transductionbody weight lossbowelbrain visualizationcaloric dietary contentcareer developmentcorpulencedetection of nutrientdiet choicediet preferencedietary choicedietary preferencesdrivingenteral feeding tubeenteric feedingfMRIfasting glucosefeedingfeeding tubefeeding-related behaviorsfluidfood choiceg-tubegastric bandinggastric bypass surgerygastric feedinggastric feeding tubegastric tubegastrointestinalghrelinglia signalingglial signalingglucagon-like peptide 1gustatory perceptiongustatory processinggustatory responsegut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghuman subjectimplantable gastric stimulation bandinginfusionsinnovateinnovationinnovativeliquidnerve signalingneuralneural signalingneuronal signalingneurotransmissionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnutrient absorptionnutrient intake activitynutrient rich foodnutrient rich mealnutrient sensingnutrient-dense mealobese patientsobesity interventionobesity surgeryobesity therapyobesity treatmentoperationoperationspathwaypatient oriented researchpatient oriented studypatients with obesityperception of nutrientspre-clinicalpreclinicalresponsesatietysmall bowelstomach bypassstomach staplingsurgerytaste processingtaste responsetube feedinguptakeweight loss surgerywt-loss
Description preview
PROJECT SUMMARY/ABSTRACT
Mechanisms underlying sustained weight loss after bariatric surgery remain unclear, though rapid nutrient
delivery is a major candidate driving decreases in caloric intake via the gut-brain axis. Preclinical models have
demonstrated the importance of the gut-brain axis in modulating short- and long-term feeding and taste…
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