grant
Contribution of IL6 trans signaling in older females after ischemic stroke
Organization UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONLocation HOUSTON, UNITED STATESPosted 15 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AD dementiaATACActemraAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAndrogenic AgentsAndrogenic CompoundsAndrogensAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoplexyB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor GeneB-Cell Differentiation Factor-2B-Cell Stimulatory Factor 2 GeneB-Cell Stimulatory Factor-2BCDFBSF-2BSF-2 GeneBSF2BSF2 GeneBeta-2 Gene InterferonBindingBiologic FactorBiologicalBiological FactorsBlocking AntibodiesBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBrainBrain Nervous SystemBrain Vascular AccidentCD126 AntigensCD126 ReceptorCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCerebrumChromatinCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexDNA ContentDNA IndexDNA PloidyDataDevelopmentDifferences between sexesDiffers between sexesDissociationDisturbance in cognitionDoseELISAElderlyEncephalonEnzyme-Linked Immunosorbent AssayEstrogensEuthanasiaExposure toFemaleFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFluorescenceFour Core GenotypesGP130GenesGoalsGonadal Steroid HormonesGonosomesHPGFHSF GeneHepatic CellsHepatic Parenchymal CellHepatocyteHepatocyte Stimulatory Factor GeneHepatocyte-Stimulating FactorHigh Risk WomanHomeHortega cellHospital AdmissionHospitalizationHourHumanHybridoma Growth FactorHybridoma Growth Factor GeneIFN-beta 2IFNB2IFNB2 GeneIL-6IL-6 GeneIL-6 ReceptorsIL-6 inhibitorIL6IL6 ProteinIL6 ReceptorsIL6 geneIL6 inhibitorIL6STIL6ST geneImmune responseImmunoblottingImpaired cognitionInfarctionInflammationInflammatoryInflammatory ResponseInjuryInterleukin 6 (Interferon, Beta 2) GeneInterleukin 6 ReceptorInterleukin 6 Signal TransducerInterleukin-6Interleukin-6 GeneInterleukin-6 inhibitorIntracellular Communication and SignalingIschemic StrokeJAK-2JAK2JAK2 geneJAK2 proteinJanus kinase 2Knock-outKnockoutLPTNLigandsLiver CellsLymphatic cellLymphocyteLymphocyticMGI-2MacrophageMarrow NeutrophilMarrow monocyteMediatingMembraneMercy KillingMessenger RNAMiceMice MammalsMicrogliaMiddle Cerebral Artery OcclusionModern ManMolecularMolecular InteractionMotorMurineMusMyeloid Differentiation-Inducing ProteinMφNeutrophilic GranulocyteNeutrophilic LeukocyteNucleusO3 exposureOutcomeOvaryPathologyPathway interactionsPatientsPhenotypePlasmacytoma Growth FactorPlayPloidiesPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPrimary Senile Degenerative DementiaPublic HealthRNA SeqRNA SplicingRNA sequencingRNAseqReceptor ProteinReceptor SignalingRecovery of FunctionResearchRoleSCM-1SCM-1aSCM1SCYC1STAT3STAT3 geneSeveritiesSex ChromosomesSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSortingSplicingStrokeT cell infiltrationTesticlesTestingTestisTherapeuticTherapeutic AndrogenTherapeutic EstrogenTyrosine-Protein Kinase JAK2Western BlottingWestern ImmunoblottingWomanX ChromosomeXCL1XCL1 geneadvanced ageafter strokeagedaged brainaged miceaged mouseagesaging brainat-risk femalesat-risk womenbehavior studybehavioral studybiologicbiological signal transductionbrain atrophybrain attackcardiac disease induced cognitive impairmentcell typecerebralcerebral atrophycerebral vascular accidentcerebrovascular accidentcerebrovascular contribution to cognitive impairment and dementiachromosome complementcognitive dysfunctioncognitive functioncognitive losscomparing females and malescomparing women and mencortical atrophycytokinedementia riskdevelopmentaldisabilityefficacious therapyefficacious treatmentelderly miceenzyme linked immunoassayfemales at high riskfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesflow cytophotometryfunctional improvementfunctional outcomesfunctional recoverygeriatricgitter cellglial activationglial cell activationgonadal steroidsgp130 Transducer Chainhigh risk femaleshomeshost responseimmune system responseimmunoresponseimprove functionimprovedimproved functional outcomesincidence of strokeinfarctinhibit IL-6inhibit IL6inhibit Interleukin-6inhibitorinjuriesinnovateinnovationinnovativeinsightinterferon beta 2knock-out animalknockout animallymph cellmRNAmRNA Expressionmalemembrane structuremenmesogliamicroglial cellmicrogliocytemonocyteneural inflammationneuroinflammationneuroinflammatoryneutrophilold ageold miceolder womenozone exposurepathwayperivascular glial cellpost strokepoststrokepre-clinical studypreclinical studyprimary degenerative dementiaprotein blottingreceptorreceptor bindingreceptor boundreceptor expressionrisk factor for dementiarisk for dementiasecretory proteinsenile dementia of the Alzheimer typesenior citizensexsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencessocial rolestroke incidencestroke outcomestroke patientstrokedstrokestargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttocilizumabtranscriptome sequencingtranscriptomic sequencingvascular cognitive impairment and dementiavascular cognitive impairment/dementiavascular contribution to impairment or dementiavascular contributions to cognition/dementiavascular contributions to cognitive decline and dementiavascular contributions to cognitive impairment and dementiawomen at high riskwomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂
Description preview
Title: Contribution of IL6 trans signaling in older females after ischemic stroke
Abstract: Women have worse outcomes after ischemic stroke than men. Multiple factors influence the outcomes including sex chromosome complement (XX vs. XY), sex hormones (estrogens vs. androgens), and immune responses. IL6 is a key inflammatory cytokine, and higher…
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