grant
Contribution of germline copy number variations to the susceptibility of aggressive prostate cancer in men of African and European ancestry
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026African AmericanAfrican ancestryAfrican descentAfro AmericanAfroamericanAmerican maleAmerican manAmerican menBiologicalCancer CauseCancer EtiologyCancersCandidate Disease GeneCandidate GeneCausalityCessation of lifeCodeCoding SystemComplexCopy Number PolymorphismDNADataDeathDeoxyribonucleic AcidDetectionDevelopmentDiseaseDisorderEtiologyEuropean ancestryExhibitsFrequenciesFunctional RNAGWA studyGWASGene Action RegulationGene Copy NumberGene DosageGene Expression RegulationGene FrequencyGene RegulationGene Regulation ProcessGenesGenetic DiversityGenetic VariationGenetic studyGenomeGenomicsGenotypeGerm LinesGoalsHealthHereditaryHeterogeneityHumanHuman GenomeIncidenceInheritedInvestigationJointsLinkMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMeta-AnalysisMethodologyModern ManNoncoding RNANontranslated RNAOutcomePathogenesisPathogenicityPopulationPopulation HeterogeneityPopulation ResearchPopulation-based researchPopulation-level researchPredispositionProstate CAProstate CancerProstate NeoplasmsProstate TumorProstate malignancyProstatic NeoplasiaProstatic NeoplasmsResolutionRiskRisk AssessmentRisk-associated variantRoleSingle Base PolymorphismSingle Nucleotide PolymorphismSusceptibilityTestingU.S. MalesUS MenUS maleUntranslated RNAVariantVariationallelic frequencybiologiccausationcopy number alterationcopy number variantcopy number variationdevelopmentaldisease causationdisparities in racedisparity due to racedisparity in ethnicdiverse populationsentire genomeethnic based disparityethnic disadvantageethnic disparityethnic inequalityethnic inequityethnicity disparityexome sequencingexome-seqfallsfull genomegene functiongenetic architecturegenome scalegenome sequencinggenome wide analysisgenome wide associationgenome wide association scangenome wide association studygenome wide studiesgenome-widegenome-wide analysisgenome-wide identificationgenomewidegenomewide association scangenomewide association studyheterogeneous populationhuman diseasehuman whole genomeimprovedinequality due to raceinequity due to raceinsightinvestigate populationlarge scale datalarge scale data setslarge scale datasetsmales in Americamales in the U.S.males in the USmales in the USAmales in the United Statesmalignancymenmen in Americamen in the U.S.men in the USmen in the USAmen in the United Statesmortalityneoplasm/cancernoncodingnovelpolygenetic risk scorespolygenic risk scorepopulation diversitypopulation investigationpopulation level investigationpopulation specific researchprostate cancer modelprostate cancer riskprostate tumor modelrace based disparityrace based inequalityrace based inequityrace disparityrace related disparityrace related inequalityrace related inequityracial disparityracial inequalityracial inequityracially unequalresolutionsrisk allelerisk generisk genotyperisk locirisk locusrisk prediction algorithmrisk prediction modelrisk stratificationrisk variantsingle nucleotide variantsocial rolestratify riskstructural mutationstructural variantstructural variationstudies of populationsstudy of the populationstudy populationsurvey populationtooltraitwhole genomewhole genome association analysiswhole genome association study
Description preview
PROJECT ABSTRACT
Inherited genetic variation is a key component in the etiology of prostate cancer (PCa). More than 450
common single nucleotide variants (SNVs) for PCa have been identified in large-scale multi-ancestry
genome-wide association studies (GWAS) and rare pathogenic SNVs in >30 PCa candidate genes have
been implicated across ancestry…
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