grant
Contribution of FGF21 and macronutrient composition towards Glp1r agonist-induced weight loss
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026ACTH-beta-Lipotropin PrecursorAdult-Onset Diabetes MellitusAffectAgonistBackBlood PlasmaBody WeightBody Weight decreasedBrainBrain Nervous SystemBreedingCNS Nervous SystemCarbohydratesCentral Nervous SystemClinical TrialsCommunicationComplexConsumptionCorticotropin-beta-Lipotropin PrecursorD-GlucoseDataData AnalysesData AnalysisDextroseDietDietary CarbohydratesDorsumDrugsEatingEffectivenessEncephalonEndocrine Gland SecretionEndorphin-ACTH PrecursorExperimental DesignsFGF-21FatsFatty acid glycerol estersFeedsFood IntakeFood PreferencesGLP-1GLP-1 RAGLP-1 agonistGLP-1 analogGLP-1 receptorGLP-1 receptor agonistGLP-I receptorGlp-1Glucagon like peptide 1 agonistGlucagon like peptide-1 receptor agonistsGlucagon-like peptide-1 analogGlucoseGoalsHigh Fat DietHormonesImaging ProceduresImaging TechnicsImaging TechniquesImpairmentIndividualIntakeIntermediate Hypothalamic RegionInvestigationInvestigatorsKO miceKetosis-Resistant Diabetes MellitusKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLearningLiverMacronutrientsMacronutrients NutritionMaintenanceMaturity-Onset Diabetes MellitusMedial HypothalamusMediatingMedicationMentorsMetabolic DiseasesMetabolic DisorderMethodsMiceMice MammalsMiddle HypothalamusModelingMurineMusNIDDMNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuroendocrinologyNeuronsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNull MouseObesityOralOutcomeOzempicPharmaceutical PreparationsPlasmaPlasma SerumPlayPro-ACTH-EndorphinPro-Opio-MelanocortinPro-OpiocortinPro-OpiomelanocortinProopiocortinProopiomelanocortinPublishingR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ActivationReceptor ProteinRegulationResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersReticuloendothelial System, Serum, PlasmaRewardsRoleRybelsusSaccharoseScientistSlow-Onset Diabetes MellitusSourceStable Diabetes MellitusStarchSucroseT2 DMT2DT2DMTechniquesTestingTherapeuticThesaurismosisTrainingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWegovyWeightWeight LossWeight Loss AgentsWeight ReductionWeight-Loss DrugsWorkWritingadiposityadult onset diabetesanalogbehavior phenotypebehavioral phenotypingbody weight losscareerclinical applicabilityclinical applicationcorpulencedata interpretationdiet choicediet preferencedietary choicedietary preferencesdietsdrug/agentexperimentexperimental researchexperimental studyexperimentsfibroblast growth factor 21food choiceglucagon-like peptide 1glucagon-like peptide-1 receptorhepatic body systemhepatic organ systeminsightketosis resistant diabetesliraglutidematurity onset diabetesmetabolic phenotypemetabolism disordermetabotypeneuronalnovelobesity managementpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmacologicpreferencereceptorresponsesemaglutidesensorskillssocial rolesugartraining opportunitytype 2 DMtype II DMtype two diabetesweightswt-loss
Description preview
Project Summary/ Abstract
Glucagon-like peptide-1 (Glp1) receptor (Glp1r) agonists are a promising new class of weight loss drugs for
treating obesity, yet weight loss outcomes to Glp1r agonists range from 0% to over 20% of starting body weight
which raises the critical question of why some individuals are more responsive than others. Previous…
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