grant
Contribution of C4b-binding protein to interactions of Neisseria gonorrhoeae with human neutrophils
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Active OxygenAdhesion MoleculeAffectAntibiotic AgentsAntibiotic DrugsAntibioticsAutomobile DrivingBacterial AdhesinsBindingBinding ProteinsBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood granulocytic cellC 4b-binding proteinC4 bC4-binding proteinC4bC4b-binding proteinCD66a antigenCD66e AntigenCEACAM1CHO CellsCarcinoembryonic AntigenCarcinoembryonic Antigen-Related Cell Adhesion Molecule 5Cell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Communication and SignalingCell SignalingCellsChimeraChimera organismChinese Hamster OvaryChinese Hamster Ovary CellClinicalColorComplementComplement 4bComplement C4bComplement InactivatorsComplement InhibitorsComplement ProteinsComplement S-ProteinCytolysisDataDevelopmentELISAElementsEnzyme-Linked Immunosorbent AssayEpibolinEquilibriumExposure toFamilyFellowshipFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGenetic TranscriptionGoalsGonococcal InfectionGonococcusGonorrheaGranular LeukocytesGranulocytic cellHumanImageImmune EvasionImmune responseImmune systemImmunoglobulin DomainImmunoglobulin-Like DomainInfectionInflammatoryInterruptionIntracellular Communication and SignalingInvestigatorsLigand Binding ProteinLigand Binding Protein GeneLysisMarrow NeutrophilMeconium Antigen 100MediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiscellaneous AntibioticModern ManMolecularMolecular InteractionMyeloid CellsN gonorrheaN. gonorrheaNeisseria gonorrhoeaeNeutrophil ActivationNeutrophilic GranulocyteNeutrophilic LeukocyteNon-specific crossreacting antigensNuclear TranslocationOutcomeOxygen RadicalsPathogenesisPathway interactionsPhagocytosisPhasePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPro-OxidantsProductionProtein BindingProteinsPublic HealthRNA ExpressionRNA SeqRNA sequencingRNAseqReactive Oxygen SpeciesReceptor ProteinReportingResearchResearch PersonnelResearchersResistanceRoleSerum ProteinsSerum Spreading FactorSexually Transmitted AgentsSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSignal TransductionSignal Transduction SystemsSignalingSiteSurfaceSurface ProteinsTestingTherapeuticTimeTrainingTranscriptionTransfectionTransgenic MiceVDAC1VDAC1 geneVaccinesVenereal DiseasesVenereal DisordersVenereal InfectionsVitronectinWorkadhesinanti-microbialantimicrobialbalancebalance functionbiological signal transductionbound proteinburden of diseaseburden of illnesscarcinoembryonal antigencarcinoembryonic antigen-related cell adhesion moleculescell adhesion proteincell typechimerascomplement 4-binding proteincomplement 4b-binding proteincomplementationdefined contributiondevelopmentaldisease burdendrivingenzyme linked immunoassayflow cytophotometrygranulocytehost responseimagingimmune evasiveimmune system responseimmunoresponseinsightmicrobialmutantneutrophilnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathogenpathwaypore forming proteinporinpreventpreventingreceptorresistantresponsesexually acquired infectionsocial rolesuccesstranscriptome sequencingtranscriptomic sequencing
Description preview
ABSTRACT
Neisseria gonorrhoeae (Gc) is the causative agent of the sexually transmitted infection gonorrhea. With an
estimated 87 million cases worldwide annually, increasing resistance to last-line antibiotics, and no protective
vaccine, Gc is an urgent public health concern. Investigating Gc-host interactions is crucial to identify new drug…
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