grant
Construction of A Lung Cancer Preclinical Model Cross-comparison Platform
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAgreementAlgorithmic AnalysesAlgorithmic AnalysisAlgorithmsAnalyses of AlgorithmsAnalysis of AlgorithmsBiological FunctionBiological ProcessCancer BiologyCancer PatientCancersCell BodyCell CommunicationCell ExtractsCell InteractionCell LineCell NucleusCell-to-Cell InteractionCellLineCellsChemicalsClassificationClinical DataCommunitiesDataData AnalysesData AnalysisData BasesData SetDatabasesDepositDepositionDifferential Gene ExpressionEnsureFeedbackGene ExpressionGeneralized GrowthGenesGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGoalsGrowthHistopathologyHumanImageImage AnalysesImage AnalysisImage data archiveIndividualInformaticsIntratumoral heterogeneityInvestigatorsLungLung NeoplasmsLung Respiratory SystemLung TumorMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMutateNucleusOat cell carcinomaPDX modelPathologicPathologyPatient derived xenograftPatientsPatternPhenotypePre-Clinical ModelPreclinical ModelsPreclinical dataProcessPublishingPulmonary CancerPulmonary NeoplasmsPulmonary malignant NeoplasmQuality ControlRecombinant DNA TechnologyResearch PersonnelResearch ResourcesResearchersResource SharingResourcesSamplingSmall Cell Lung CancerStaining methodStainsStandardizationStatistical MethodsStrains Cell LinesSystematicsTherapeuticTissue GrowthTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTranslationsanalysis pipelineanalytical toolanti-cancer researchcancer microenvironmentcancer researchcohortcomparativecost effectivecultured cell linedata basedata explorationdata integrationdata interpretationdata resourcedigitalexperimentexperimental researchexperimental studyexperimentsfeature extractiongenetically engineeredheterogeneity in tumorsimage archival systemimage archiveimage evaluationimage interpretationimage libraryimage repositoryimagingimaging repositoryimprovedin vivo Modelinformatics toolintra-tumoral heterogeneityintratumor heterogeneitylung cancerlung oat cell carcinomalung small cell neuroendocrine carcinomamalignancymolecular profilemolecular signaturemouse modelmurine modelneoplasm/canceroat cell canceronline appontogenyoutcome predictionpathology imagingpatient derived xenograft modelpicture archivepre-clinical assessmentpreclinical assessmentpreclinical findingspreclinical informationpublic repositorypublicly accessible repositorypublicly available repositoryresponsesmall cell lung carcinomasmall cell undifferentiated carcinomaspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial molecular analysisspatial molecular imagingspatial molecular mappingspatial molecular profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstatistic methodstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranscriptome profilingtranscriptomic profilingtranslationtumortumor heterogeneitytumor microenvironmentuser-friendlyvalidation studiesweb appweb applicationweb based appweb based application
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Project Summary
Preclinical models of lung cancer are essential tools for researchers to understand cancer biology and develop
therapeutic strategies. Choosing the most cost-effective preclinical model to answer a specific scientific question
requires careful study of the existing molecular and pathological characterization of different models and…
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