grant

Constructing 3D voxelated tissues with molecular architecture encoded modular biomaterials to understand and control stem cell function

Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressArchitectureAreaBehaviorBiocompatible MaterialsBiologicalBiological FunctionBiological ProcessBiomaterialsBiomedical EngineeringBody TissuesCell BodyCell CommunicationCell InteractionCell-Extracellular MatrixCell-to-Cell InteractionCellsDysfunctionECMElasticityEncapsulatedEngineeringEngineering / ArchitectureExtracellular MatrixFunctional disorderGelLocationMechanicsMolecularOrganization ChartsPhysicsPhysiopathologyPolymer ChemistryPolymersPrintingProgenitor CellsRelaxationResearchShapesTechnologyTestingTimeTissuesTrainingVariantVariationactive life styleactive lifestyleactive livingbio-engineeredbio-engineersbio-printingbioengineeringbioinkbiologicbiological engineeringbiological materialbioprintingcell assemblycell typedesigndesigningflexibilityflexiblein vitro Modelknowledge of resultsmechanicmechanicalmechanical propertiesorganizational structurepathophysiologypolymerpolymericprogenitor cell functionprogenitor cell nicheprogenitor functionprogenitor nicheprogramspublic health relevancestem and progenitor cell functionstem and progenitor cell nichestem and progenitor functionstem cell functionstem cell nichestem cellstechnology platformtechnology systemthree dimensionaltoolviscoelasticity
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PROJECT SUMMARY
Most biological tissues are not simply static materials but active living composites. They are composed of living

cells dispersed in nonliving polymers known as extracellular matrix. Decades of research in biomaterials have

demonstrated a multitude of ways in which polymeric materials can influence cells, and cells can modify…

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Constructing 3D voxelated tissues with molecular architecture encoded modular biomaterials to understand and control ste | Dev Procure