grant
Consequences of retrotransposition on genome integrity
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Adenocarcinoma of the EsophagusBarrett EsophagusBarrett SyndromeBarrett UlcerBioinformaticsBiologicalBody TissuesBurn injuryBurnsCancersCell BodyCellsCellular TransformationCellular biologyChromosomal InstabilityChromosome InstabilityChromosomesClonal ExpansionColon CancerColon CarcinomaColumnar Epithelial-Lined Lower EsophagusColumnar-Lined EsophagusComplementary DNAComputer AnalysisDNADNA DamageDNA Damage RepairDNA InjuryDNA Molecular BiologyDNA RearrangementDNA RepairDNA Sequence RearrangementDNA Transposable ElementsDNA copy numberDNA mutationDNA seqDNA sequencingDNAseqDataData SetDeoxyribonucleic AcidDependenceDetectionDevelopmentDicentric chromosomeEC 2.7.7.49ElementsEsophageal AdenocarcinomaEsophageal CancerEsophagus CancerEventEvolutionExperimental ModelsGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric Pylorus CancerGene RearrangementGene TranscriptionGenesGenetic ChangeGenetic DiversityGenetic ScreeningGenetic TranscriptionGenetic VariationGenetic defectGenetic mutationGenetic studyGenomeGenome InstabilityGenomic InstabilityGenomicsHigh PrevalenceHumanHuman GeneticsIn VitroInsertion MutationInvestigatorsJointsKnowledgeLaboratoriesLesionLong Interspersed ElementsMalignantMalignant - descriptorMalignant CellMalignant Esophageal NeoplasmMalignant Esophageal TumorMalignant Gastric NeoplasmMalignant Gastric TumorMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Pancreatic NeoplasmMalignant TumorMalignant Tumor of the EsophagusMalignant Tumor of the LungMalignant Tumor of the OvaryMalignant neoplasm of esophagusMalignant neoplasm of lungMalignant neoplasm of ovaryMalignant neoplasm of pancreasMalignant neoplasm of prostateMalignant prostatic tumorMediatingMethodsMethylationModelingModern ManMolecularMolecular BiologyMonitorMutationNon-Polyadenylated RNAORFsOncogenesisOpen Reading FramesOutcomeOvary CancerPancreas CancerPancreatic CancerPathologyPopulationPrevalenceProcessProstate CAProstate CancerProstate malignancyProtein Coding RegionProteinsPulmonary CancerPulmonary malignant NeoplasmRNARNA ExpressionRNA Gene ProductsRNA TranscriptaseRNA-Binding ProteinsRNA-Dependent DNA PolymeraseRNA-Directed DNA PolymeraseResearch PersonnelResearchersResolutionRetrotranspositionRetrotransposonReverse TranscriptaseReverse TranscriptionRevertaseRibonucleic AcidRoleS PeriodS phaseShotgunsSomatic MutationSourceStomach CancerSynthesis PeriodSynthesis PhaseSystemTCGATestingThe Cancer Genome AtlasTherapeuticTissuesTranscriptionTransposable ElementsUnscheduled DNA SynthesisWorkanalytical methodbiologicburnedcDNAcancer cellcancer cell genomecancer genomecancer in the coloncancer preventioncancer typecell biologycomputational analysescomputational analysiscomputer analysescopy number alterationdevelopmentalendonucleaseentire genomeesophageal intestinal metaplasiaexperimentexperimental researchexperimental studyexperimentsfull genomegastric malignancygenome analysisgenome integritygenome mutationgenome sequencinggenomic datagenomic datasetgenomic integritygenomic rearrangementhuman diseasehuman tissuein vitro Modelinsightlive cell imagelive cell imaginglive cellular imagelive cellular imaginglung cancermalignancymalignant stomach neoplasmmalignant stomach tumormetaplastic cell transformationneoplasm/cancernew approachesnovel approachesnovel strategiesnovel strategyoesophageal cancerovarian canceroverexpressoverexpressionpancreatic malignancyprecancerprecancerouspremalignantpromoterpromotorreplication stressresolutionsshot gunsocial rolesomatic variantstomach fundus cancerstomach pylorus cancertumortumor genometumorigenesiswhole genome
Description preview
Project Summary
Transposable elements are a major source of human genetic variation and also contribute to human diseases by causing somatic mutations. The activity of transposition in human cancers is well established. Both expression of the RNA binding protein ORF1p encoded by the L1 element and insertions of L1 and other transposons are…
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