grant
Conditional and female lethal approaches for mosquito control
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 21 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025A. aegyptiAdes aegyptiAe. AegyptiAedes aegyptiAllelesAllelomorphsAntidotesArboviralArbovirusesArthropod-Borne VirusesBody TissuesCRISPRCRISPR gene driveCRISPR-Cas9 gene driveCRISPR-Cas9 mediated gene driveCRISPR/Cas systemCRISPR/Cas9 based gene driveCalibrationCas9-based gene driveClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats gene driveCoupledCulicidaeDNA Restriction EnzymesDataDengueDevelopmentDisadvantagedDisease VectorsElementsEngineeringEpidemiologyEssential GenesExposure toExtinctionFailureFemaleFixationFrequenciesFutureGene ConversionGene ModifiedGenerationsGenesGenomeGoalsGuide RNAHealthHeat ShockHeat-Shock ReactionHeat-Shock ResponseHigh temperature of physical objectHomeHomingHumanInsectaInsectsInsects InvertebratesLethal GenesLinkMasculineMasculinityMediatingMedicalMitochondriaModelingModern ManMosquito ControlMosquitoesOutcomePerformancePhenotypePopulationPopulation DynamicsPropertyRegulatory ElementRepressionResistanceRestriction EndonucleasesRunningSafetySeriesSiteSystemTarget PopulationsTechniquesTechnologyTemperatureTheriacsTimeTissuesToxinTransgenesTransmissionWorkcostdesigndesigningdevelopmentalepidemiologicepidemiologicalexperimentexperimental researchexperimental studyexperimentsfitnessgRNAgene functiongene modificationgenetically modifiedhigh temperaturehomeshoming driverhoming gene driveimprovedinsightinterestlife historymitochondrialnovelpromoterpromotorrepairrepairedresistance alleleresistantresistant allelesample fixationsexsimulationsmall moleculespatial and temporalspatial temporalspatiotemporalsterile insect techniquetooltransgenetransgene expressiontransmission processvectorvector control♀
Description preview
PROJECT SUMMARY
Gene drives (GDs) are a cutting-edge technology with the potential to improve human health, but gene
drives have many limitations that impede their useful application in the wild, particularly population suppression
drives. GD spread needs to outpace the fitness cost imposed on the population; otherwise, the GD will be
rapidly…
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