grant
Computational Methods for In-Situ Structure Determination using Cryo-ET
NIHUS FederalResearch GrantFY2026AccelerationAddressAdoptionBindingBiologicalBiologyBiomedical ResearchCell BodyCellsComputing MethodologiesCryo-electron tomographyDevelopmentDisciplineDiseaseDisorderEnsureEnvironmentGoalsImaging ProceduresImaging TechnicsImaging TechniquesImprove AccessIn SituInstructionMedicalMethodsModernizationMolecularMolecular InteractionPlayPreparationProtein AnalysisProteinsResolutionRibosomesRoleSamplingStructural BiologistStructureTechnologyVisualizationaccess restrictionsbiologiccombatcomputational methodologycomputational methodscomputer based methodcomputer methodscomputerized data processingcomputing methodcryo-EM tomographycryoEM tomographycryoelectron tomographydata acquisitiondata acquisitionsdata processingdevelopmentalelectron cryo-tomographyempowermenthigh definitionhigh-resolutionimage processinginterestmacromoleculemethod developmentparticlepreparationsprotein complexpublic health relevanceresolutionssocial roletool
Description preview
PROJECT SUMMARY
Understanding how proteins interact within the cell to perform specific functions is a central goal of modern
biology and crucial for understanding the diverse roles these molecules play in biomedicine. Single-particle
cryo-electron tomography (SP-cryo-ET) is currently the only technology capable of visualizing macromolecules
in…
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