grant
Computational methods for discovery of disease-modulating microbial genes
Organization WISTAR INSTITUTELocation PHILADELPHIA, UNITED STATESPosted 1 May 2024Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AddressAdoptedAdverse ExperienceAdverse eventAffectBacteriaBody TissuesCancersCommunitiesComputing MethodologiesDataData BasesDatabasesDetectionDevelopmentDiagnosisDiseaseDisease MarkerDisease OutcomeDisorderGI microbiomeGene ExpressionGenesGoalsHealthHomologous ProteinHumanImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIntervention StrategiesInvestigatorsLinkMachine LearningMalignant NeoplasmsMalignant TumorMapsMethodsMicrobeModelingModern ManNon-Polyadenylated RNAOutcomePathogenicityPatientsPeptidesProtein DatabasesProtein HomologProteinHomologProteinsPublishingRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqResearchResearch PersonnelResearchersRibonucleic AcidRoleShotgun SequencingShotgunsTechniquesTechnologyTissuesViralVirusbiomarker developmentbiomarker discoverycancer typecomputational frameworkcomputational methodologycomputational methodscomputer based methodcomputer frameworkcomputer methodscomputing methoddata basedeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydetection methoddetection proceduredetection techniquedevelop softwaredeveloping computer softwaredevelopmentaldiagnostic approachdiagnostic strategydigestive tract microbiomedisease prognosisdisease prognosticationenteric microbiomegastrointestinal microbiomegut microbesgut microbial speciesgut microbiomegut-associated microbiomehost responsehuman RNA sequencinghuman RNA-seqhuman diseasehuman tissueimmune system responseimmunoresponseimprovedinnovateinnovationinnovativeintestinal biomeintestinal microbesintestinal microbiomemachine based learningmalignancymetagenome sequencingmetagenomic sequencingmicrobialneoplasm/cancernew diagnosticsnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext generation diagnosticsnovelnovel diagnosticsnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachprognosticationrapid detectionresponsesequencing platformshot gunsocial rolesoftware developmenttranscriptome sequencingtranscriptomic sequencingtreatment strategyuser friendly computer softwareuser friendly softwareviral detectionvirus detection
Description preview
ABSTRACT
Microbial genes in gut and diseased tissues were recently linked with progression and outcomes of different
human diseases, including cancer and immune diseases. Deciphering the pathogenic roles of different microbial
genes can improve diagnosis, prognostication, and treatment of human diseases. Yet, current methods for RNA
and shotgun…
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