grant
Computational methods for detecting patterns of complex genomic variation
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Jan 2016Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAlgorithmic SoftwareAlgorithmic ToolsAlgorithmsArchitectureBody TissuesCRISPRCRISPR/Cas systemCancersCell BodyCellsChromatinChromosome MarkersClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCollectionCombinatorial OptimizationComplexComputational algorithmComputer Software ToolsComputer softwareComputing MethodologiesConstitutionDNA ContentDNA Damage RepairDNA IndexDNA PloidyDNA RearrangementDNA RepairDNA Sequence RearrangementDNA lesionDevelopmentDiagnostic testsDiseaseDisorderDrynessEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionGene Action RegulationGene ExpressionGene Expression RegulationGene RearrangementGene RegulationGene Regulation ProcessGeneticGenetic DiseasesGenomeGenome MappingsGenomic SegmentGenomicsGenotypeGerm LinesGoalsGrantGraphHaploidHaploidyHi-CIndividualKaryotypeKaryotype determination procedureKaryotypingKaryotyping GeneticsMalignant NeoplasmsMalignant TumorMediatingMethodsModelingMolecular ConfigurationMolecular ConformationMolecular StereochemistryOpticsOutputPathologicPathologyPatternPhenotypePloidiesProcessProtocolProtocols documentationPublicationsSamplingScientific PublicationShapesSoftwareSoftware AlgorithmSoftware ToolsStructureTechnologyTimeTissuesTumor PathologyUnscheduled DNA SynthesisVariantVariationWorkcancer cell genomecancer genomecell typechromosome complementclinical applicabilityclinical applicationclinical relevanceclinically relevantcombinatorialcomputational methodologycomputational methodscomputer algorithmcomputer based methodcomputer methodscomputing methodconformationconformationalconformational stateconformationallyconformationscostdetection methoddetection proceduredetection techniquedevelopmentalemerging sequencing technologyenvironmental changeepigeneticallyexperimentexperimental researchexperimental studyexperimentsextrachromosomal DNAgenetic conditiongenetic disordergenome scalegenome segmentgenome-widegenomewidegenomic rearrangementgenomic regiongenomic variationimprovedinsightkaryogrammalignancymosaicnanonano porenanoporeneoplasm/cancernew sequencing technologynew technologynovelnovel sequencing technologynovel technologiesopticalpostnatalprenatal screeningprenatal testingreconstructionreference assemblyreference genomesoftware toolkitstructural mutationstructural variantstructural variationthree dimensionaltooltumor genome
Description preview
Project Summary
Rearrangements of genomic segments or structural variation (SVs), include changes (increase/decrease)
of copy number, inversions, translocations, and other mechanisms that change or rearrange the DNA
content of a cell. Complex SVs can mediate many constitutional diseases; highly pathological germline
rearrangements can damage the…
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