grant
Computational Feature Profiling and Modeling for Prostate Cancer Detection and Risk Stratification
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 5 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2026AccountingAddressAggressionAggressive behaviorAmerican maleAmerican manAmerican menBenignBiochemicalBiological MarkersBiopsyBiopsy SampleBiopsy SpecimenBlood SerumBody TissuesCancer CauseCancer DetectionCancer EtiologyCancer PatientCancersCell Communication and SignalingCell SignalingCessation of lifeClinicalClinical DataClinical MarkersClinical TreatmentComputational TechniqueConvNetCore BiopsyCore Needle BiopsyDNADataData SetDeathDecision MakingDeoxyribonucleic AcidDevelopment and ResearchDiagnosisDiagnosticDiseaseDisorderEC 3.4.21.34EvaluationFunctional ImagingGeneticGenetic RiskGenomicsGerm LinesGoalsGraphH and EHealthHematoxylin and EosinHematoxylin and Eosin Staining MethodHistologyImageImage AnalysesImage AnalysisIndividualIndolentInstitutionInterventionIntracellular Communication and SignalingKallikrein 3LearningLinkLocal TherapyLocalized TherapyMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMeasuresMedical ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModelingMonitorMorbidityNCI OrganizationNMR ImagingNMR TomographyNational Cancer InstituteNomogramsNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresOutcomeP-30 AntigenPSA AssayPatientsPerformancePhenotypePhysiciansPhysiologic ImagingPlasma Kallikrein PrecursorPlasma PrekallikreinProbabilityProcessProstateProstate CAProstate CancerProstate GlandProstate Specific Antigen AssayProstate Specific Antigen PreproproteinProstate malignancyProstate specific antigen measurementProstate-Specific AntigenProstatectomyProstatic GlandProstatovesiculectomyR & DR&DRadiation therapyRadical ProstatectomyRadiotherapeuticsRadiotherapyRectumRecurrenceRecurrentResearchResearch ResourcesResearch SpecimenResolutionResourcesRiskRisk FactorsSamplingScreening for Prostate CancerSemenogelaseSemininSerumSignal TransductionSignal Transduction SystemsSignalingSourceSpecificitySpecimenStaining methodStainsSurgicalSurgical InterventionsSurgical ProcedureTestingTissuesTrainingU.S. MalesUS MenUS maleUniversitiesWashingtonWorkZeugmatographyalgorithm developmentbio-markersbiologic markerbiological signal transductionbiomarkercancer diagnosiscancer geneticscancer riskclinical biomarkersclinical decision-makingclinical interventionclinical therapyclinically useful biomarkerscohortconvolutional networkconvolutional neural netsconvolutional neural networkcostdetect prostate cancerdigitalfunctional outcomesgamma-Seminoproteingraph attention networkgraph convolutional networkgraph neural networkhK3 Kallikreinhigh definitionhigh-resolutionimage evaluationimage interpretationimagingimaging in the prostatelarge data setslarge datasetsmales in Americamales in the U.S.males in the USmales in the USAmales in the United Statesmalignancymenmen in Americamen in the U.S.men in the USmen in the USAmen in the United Statesmulti-modal datamulti-modal datasetsmulti-modalitymulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultimodal datamultimodal datasetsmultimodal modelingmultimodalitymultiscale computational modelingmultiscale mathematical modelingmultiscale modelingneoplasm/cancernetwork modelsnew markernovelnovel biomarkernovel markerover-treatmentovertreatmentpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesphysiological imagingpredict clinical outcomepreventpreventingprostate cancer detectionprostate cancer early detectionprostate cancer modelprostate imagingprostate tumor modelradiation treatmentresearch and developmentresolutionsrisk stratificationscreeningscreeningsserum PSAserum prostate specific antigenstratify risksurgerytooltreatment with radiationtrial regimentrial treatmenttumorunnecessary treatment
Description preview
PROJECT SUMMARY/ABSTRACT
Prostate cancer is the most common and second deadliest non-skin cancer in American men, accounting for
26% of new cancer diagnoses and 9% of cancer deaths in men. Active surveillance, radical prostatectomy and
radiotherapy are commonly used treatments for clinically localized prostate cancer. However, current risk…
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