grant
Computational and experimental approaches for decoding the function and regulation of unconventional RNA translation
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 1 Jan 2025Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20263' Untranslated Regions3'UTR5' Untranslated Regions5'UTRAddressBiologicalBiologyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell ProliferationCell SignalingCellular ProliferationCodeCoding SystemComplexComputational BiologyComputational toolkitDarknessDataDevelopmentDiagnosisDiseaseDisorderEstrogensEukaryotic CellEventFunctional RNAGenesGoalsHID proteinInitiation CodonInitiator CodonIntracellular Communication and SignalingInvestigationInvestmentsIsoformsKnowledgeMachine LearningMeasurementNamesNon-Polyadenylated RNANoncoding RNANontranslated RNAORFsOpen Reading FramesPhysiologicPhysiologicalPhysiologyPlayProtein Coding RegionProtein IsoformsProteinsProteomeRNARNA Gene ProductsRegulationRegulatory ElementResearchRibo-seqRibonucleic AcidRoleSignal TransductionSignal Transduction SystemsSignalingSiteStart CodonTherapeuticTherapeutic EstrogenTrans-Acting FactorsTrans-ActivatorsTransactivatorsTranslation InitiationTranslationsUntranslated RNAbiologicbiological signal transductioncomputational toolboxcomputational toolscomputational toolsetcomputer biologycomputerized toolsdevelopmentalfunctional genomicsgenome scalegenome-widegenomewidehead involution defective gene producthead involution defective proteinhid gene producthigh definitionhigh-resolutionhuman diseaseinsightmRNA Leader Sequencesmachine based learningnamenamednamingnoncodingnovelprogramsprotein protein interactionpublic health relevanceribosome footprint profilingribosome profilingsocial roletooltranslationtranslational modeltranslatome
Description preview
ABSTRACT
The advent of ribosome profiling (Ribo-seq) has enabled high-resolution measurement of translation at a
genome-wide level, known as the translatome. Studies based on Ribo-seq have revealed a complex
translational landscape in eukaryotic cells, uncovering translations beyond conventionally annotated events
that may potentially yield…
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