grant
Computation-aided Molecular Design of DNA-Inspired Janus Base Biomaterials for Intracellular Delivery
Organization UNIVERSITY OF CONNECTICUT STORRSLocation STORRS-MANSFIELD, UNITED STATESPosted 15 Sept 2024Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Anti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesBase PairingBehaviorBindingBiocompatible MaterialsBiodistributionBiomaterialsBlood Circulation TimeBody TissuesCartilage DiseasesCell BodyCellsChemicalsClinicComputing MethodologiesCytoplasmDNADeoxyribonucleic AcidDrugsEffectivenessEndocytosisEndosomesFamilyFutureGenesGoalsHealthIn VitroIndustrializationInfiltrationIntravenousKidneyKidney DiseasesKidney Urinary SystemKnowledgeLifeLiverMacrogolsMedicationMessenger RNAMethodologyMethodsMissionModificationMolecularMolecular InteractionNamesNanotubesNational Institutes of HealthNatureNephropathyNeurofibrillary TanglesNon-Polyadenylated RNAOrganismPatientsPenetrationPharmaceutical PreparationsPolyethylene GlycolsPolyethylene OxidePolyethyleneoxidePolymersPolyoxyethylenesProcessPropertyProteinsPublic HealthPublishingRNARNA Gene ProductsRNA based therapeuticsRNA based therapyRNA deliveryRNA therapyReceptosomesRenal DiseaseResearchRibonucleic AcidRodSerum ProteinsShapesSideSmall RNASurfaceTechnologyTestingTherapeuticTissuesUnited States National Institutes of HealthValidationWorkarticular cartilagebasebasesbiological materialcartilage disordercomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddeliver mRNAdeliver messenger RNAdelivery system for mRNAdelivery vectordelivery vehicledesigndesigningdisabilitydrug/agentendosome membraneexperimentexperimental researchexperimental studyexperimentshepatic body systemhepatic organ systemimmunogenicityimprovedin silicoin vivokidney disorderlipid based nanoparticlelipid nanoparticleliving systemmRNAmRNA deliverymessenger RNA deliverynamenamednamingnano particlenano-sized particlenanoparticlenanosized particleneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologynovelparticlepolymerpolymericrenalrenal disorderresponseself assemblysmall moleculetangletechnological research and developmenttechnology research and developmenttherapeutic RNAtoolvalidations
Description preview
Abstract
The overall goal of this proposal is to develop novel biomaterials for intracellular therapeutics delivery.
While messenger RNAs (mRNAs) are recognized as promising candidates for RNA therapeutics (such as anti-
inflammatory drugs) as well as research tools (such as delivering Cas9 mRNA for gene editing), unlike many
chemical molecules…
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