grant
Comprehensive analysis of macromolecule structural variability in CryoEM/CryoET
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 21 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAlgorithmsAmino Acid SequenceBehaviorBiochemistryBiological ChemistryBiological FunctionBiological ProcessCell BodyCell Communication and SignalingCell SignalingCellsClassificationComplexComputational toolkitComputer Software ToolsComputing MethodologiesCryo-electron MicroscopyCryoelectron MicroscopyData SetElectron CryomicroscopyEnvironmentExerciseGaussian modelGaussian statisticsGaussianityGaussianity modelGoalsHeterogeneityHomologous ProteinIceImageIn SituIndividualIntracellular Communication and SignalingInvestigatorsKnowledgeMapsMemoryMethodsModelingModernizationMolecular ConfigurationMolecular ConformationMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular StereochemistryMovementNoisePrimary Protein StructurePropertyProtein AnalysisProtein ConformationProtein HomologProteinHomologProteinsProtocolProtocols documentationResearch PersonnelResearchersResolutionRotationSamplingSignal TransductionSignal Transduction SystemsSignalingSoftware ToolsStructureStructure-Activity RelationshipSumSystemSystematicsTOMOTomogramVisualizationWorkbiological signal transductionbiological systemsbody movementchemical structure functioncombatcomputational methodologycomputational methodscomputational toolboxcomputational toolscomputational toolsetcomputer based methodcomputer methodscomputerized data processingcomputerized toolscomputing methodconformationconformationalconformational stateconformationallyconformationscostcryo-EMcryoEMcryogenic electron microscopycryogenicsdata processingdeep learning based neural networkdeep learning neural networkdeep neural netdeep neural networkdensitydynamic systemdynamical systemelectron tomographyflexibilityflexibleimaginginnovateinnovationinnovativeinsightmacromoleculemicroscope imagingmicroscopic imagingmicroscopy imagingmolecular modelingnovelparticleprotein complexprotein sequenceprotein structureprotein structuresproteins structureresolutionssoftware toolkitstructural biologystructure function relationshipthree dimensional
Description preview
Project Summary
This proposal aims to develop computational tools that analyze the structural variability of the
macromolecules imaged by Cryogenic electron microscopy (CryoEM) and Cryogenic electron tomography
(CryoET). As the function of most macromolecules involves dynamic interactions among their own
components or with other molecules, the…
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