grant
Complexity of Protein Tyrosine Phosphatase Oxidation
Organization STATE UNIVERSITY OF NEW YORK AT ALBANYLocation ALBANY, UNITED STATESPosted 1 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025ATP-protein phosphotransferaseBiologicalCausalityCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCholesterolComplexCoupledCysteineCytosolic Protein Tyrosine PhosphastaseDephosphorylationDiseaseDisorderEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEnzyme GeneEnzymesEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorEquilibriumEtiologyFamilyGoalsH2O2Half-CystineHydrogen PeroxideHydroperoxideIntracellular Communication and SignalingKinase Family GeneKnowledgeL-CysteineLinkMediatingModalityOxidantsOxidation-ReductionOxidizing AgentsPTP Family GenePTPasePathway interactionsPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhosphorylationPhosphotyrosine PhosphatasePhosphotyrosyl Protein PhosphatasePhysiologicPhysiologicalPilot ProjectsProductionProductivityProtein DephosphorylationProtein FamilyProtein KinaseProtein PhosphorylationProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProtein Tyrosine PhosphataseProtein Tyrosine Phosphatase GeneProteinsPublishingReceptor Type PTP GeneRedoxRegulationResearchResearch ResourcesResourcesSeminalSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSubcellular ProcessTherapeuticTyrosine KinaseTyrosine PhosphataseTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosyl Phosphoprotein PhosphataseTyrosylprotein Kinasebalancebalance functionbiologicbiological signal transductioncausationdisease causationelectron acceptorglycogen synthase a kinasehydroxyalkyl protein kinasehydroxyaryl protein kinasein vivoinsightmembernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoxidationoxidation reduction reactionpathwayphosphorylase b kinase kinasepilot studyprogramsprotein functionprotein tyrosine phosphate phosphohydrolaseresponsesmall moleculetranslational opportunitiestranslational potentialtyrosyl protein kinase
Description preview
Project Summary
The long-term goal of my research program is to elucidate redox signaling mechanisms underlying disease
initiation and progression and develop therapeutic strategies that target deregulated pathways. In a physiological
context, the reversible oxidation of reactive cysteine residues within proteins elicits a spectrum of structural…
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