grant
Complement resistance and acute lung injury during Klebsiella pneumoniae infection
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 10 Mar 2026Deadline 9 Mar 2029
NIHUS FederalResearch GrantFY2025Acute Lung InjuryAcute Pulmonary InjuryAllelesAllelomorphsAnaphylatoxinsAntibiotic AgentsAntibiotic DrugsAntibioticsBacteriaBacterial InfectionsBindingBinding SitesBloodBlood Reticuloendothelial SystemBlood SerumBronchoalveolar Lavage FluidC 5b-9C5 aC5aC5a ReceptorsC5a anaphylatoxin receptorC5bC5b-9CD88 AntigensCapsulesCell BodyCell CountCell NumberCellsClinicalCombining SiteComplementComplement 5aComplement 5a ReceptorComplement ActivationComplement C 5bComplement C5aComplement Complex C5b-9Complement InactivatorsComplement InhibitorsComplement Membrane Attack ComplexComplement ProteinsCytolysisCytolytic Terminal Complement ComplexDNA mutationDepositDepositionDevelopmentDisease OutbreaksELISAEnzyme-Linked Immunosorbent AssayEpidemicFutureGeneticGenetic ChangeGenetic defectGenetic mutationGenomic approachHealth CareHistopathologyHospital InfectionsHospital acquired infectionHospitalsHost DefenseHumanImmuneImmune Modulation TherapyImmune mediated therapyImmune systemImmunesImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyInfectionInflammatory ResponseInterventionInvestigatorsK pneumoniaeK. pneumoniaeKlebsiella pneumoniaeKnock-outKnockoutLiverLungLung InflammationLung Respiratory SystemLung damageLysisMeasurementMeasuresMediatingMembraneMembrane Attack ComplexMentorshipMiceMice MammalsMiscellaneous AntibioticModelingModern ManMolecular InteractionMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMurineMusMutationNosocomial InfectionsNosocomial pneumoniaOropharyngealOropharynxOropharynxsOutbreaksPathogenicityPathway interactionsPhysiciansPneumoniaPneumonitisPredispositionPreventionProductionPulmonary InflammationReactive SiteRecombinant C5aReportingResearch PersonnelResearchersResistanceResistance profileResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant profileResistant to Multiple DrugResistant to multi-drugResistant to multidrugRoleScientistSerumSpleenSpleen Reticuloendothelial SystemSusceptibilityTerminal Complement ComplexTestingTherapeuticTrainingUronic AcidsVariantVariationWild Type Mouseantagonismantagonistaspiratebacteria infectionbacterial diseasecapsulecombatcomparative genomicscomplement 5bcomplement C5bcomplement pathway regulationcomplement systemcomplementationcytokinedevelopmentalenzyme linked immunoassaygenetic approachgenetic strategygenome mutationgenomic effortgenomic strategyhealthcare-associated pneumoniahepatic body systemhepatic organ systemhospital acquired pneumoniahospital associated pneumoniaimmune drugsimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmune-modulation treatmentimmuno therapyimmunologic therapeuticsimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentimmunotherapeuticsimmunotherapy agentin vitro Assayin vivoinsightinstitutional infectionlung injurymembrane structuremouse modelmulti-drug resistantmultidrug resistantmurine modelnovelopportunistic pathogenoral pharyngealpathogenpathwaypneumonia modelpneumonia modelspreventpreventingpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryresistance in K pneumoniaeresistance in K. pneumoniaeresistance in Klebsiella pneumoniaeresistantresistant K pneumoniaeresistant K. pneumoniaeresistant Klebsiella pneumoniaeskillssmall moleculesocial rolestemsuccesstherapeutic immunomodulationtherapeutic immunoregulationwildtype mouse
Description preview
PROJECT SUMMARY
Hospital-acquired pneumonia caused by multidrug-resistant Klebsiella pneumoniae (KP) poses a significant
challenge in clinical settings due to limited therapeutic options. Immunotherapy has emerged as a promising
strategy against such infections. To inform the development of immunomodulatory therapies to target this
pathogen, it is…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click