grant

Comparative Bioenergetics of Aging

Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 15 Jul 2015Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AchievementAchievement AttainmentAffectAgeAgingAlabamaAllyAnimalsAntioxidantsBioenergeticsBiology of AgingBody SystemBody TissuesCancersCell AgingCell BodyCell Communication and SignalingCell EnergeticsCell FunctionCell PhysiologyCell ProcessCell SenescenceCell SignalingCellsCellular AgingCellular FunctionCellular PhysiologyCellular ProcessCellular SenescenceChronic DiseaseChronic IllnessCirculatory CollapseCollaborationsCommon Rat StrainsComparative BiologyComplexDNA Damage RepairDNA RepairDataDisciplineDiseaseDisorderDissectionEducationEducation and TrainingEducational aspectsEducational workshopEnergy ExpenditureEnergy MetabolismEnvironmentEvolutionFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FatsFatty acid glycerol estersFosteringGeneral PopulationGeneral PublicGeroscienceGoalsGrantHealthHeterogeneityHourHumanHumulin RIncrease lifespanInfrastructureInsulinIntermediary MetabolismInternationalIntracellular Communication and SignalingInvestigatorsInvestmentsKnowledgeLaboratoriesLength of LifeLifeLinkLocationLongevityMalignant NeoplasmsMalignant TumorMammaliaMammalsMechanistic Target of RapamycinMetabolicMetabolic ProcessesMetabolismMethodologyMethodsMitochondriaModelingModern ManNovolin ROrgan SystemOrganismPatternPhysical activityPopulationPostdocPostdoctoral FellowPrimatesPrimates MammalsProcessProductionProductivityRAFT1RatRats MammalsRattusRegular InsulinReplicative SenescenceReproductionResearchResearch AssociateResearch PersonnelResearch ResourcesResearchersResourcesScientistServicesShockSignal TransductionSignal Transduction SystemsSignalingSpecialistSubcellular ProcessTemperatureTissuesTrainingTraining SupportTraining and EducationUniversitiesUnscheduled DNA SynthesisUpdateWorkshopage related pathwaysagesaging associated mechanismaging mechanismaging pathwayaging processaging related mechanismaging related pathwaysbiological mechanism of agebiological pathways of agebiological signal transductionboost longevitycareercell typechronic disordercirculatory shockcomparativeconferenceconventioncostdata analysis coredata analysis research coredata analytics coredata analytics research coreeat lesselongating the lifespanenhance longevityexperimentexperimental researchexperimental studyexperimentsextend life spanextend lifespanextend longevityfoster longevitygeroscientificgraduate studentimprove lifespanimprove longevityinnovateinnovationinnovativeinstrumentationinterestlater in lifelater lifelifespan extensionliving systemmTORmalignancymammalian target of rapamycinmechanism regulating agingmechanisms involved in agingmetabolic ratemitochondrialneoplasm/cancernoveloutreachpathway involved in agingpost-docpost-doctoralpost-doctoral traineeprolong lifespanprolong longevitypromote lifespanpromote longevityprotein homeostasisproteostasisreduced eatingreduced food intakeregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissuerepairrepairedreplicative agingresearch associatesresponseshockssummitsupport longevitysymposiasymposiumtissue regenerationtissue regrowthtissue renewaltissue specific regenerationundergradundergraduateundergraduate studentvirtual
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Comparative Bioenergetics of Aging (Overall) Project Summary
Aging and energetics are inextricably intertwined. That simple, inescapable fact has been clear since the earliest

discoveries that long-lived mammal species typically expend cellular energy at a slower rate than short-lived

species, that the longevity of poikilothermic animals was…

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Comparative Bioenergetics of Aging — UNIVERSITY OF ALABAMA AT BIRMINGHAM | UNITED STATES | Jul 2015 | Dev Procure