grant
Combining Molecular Simulations and Biophysical Methods to Characterize Conformational Dynamics of the HIV-1 Envelope Glycoprotein
Organization DREXEL UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 10 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAccelerationAnti-viral TherapyAntigensBindingBiophysicsCell BodyCellsCharacteristicsComplexCrosslinkerDataDevelopmentEquilibriumFRETFluorescence Resonance Energy TransferFutureFörster Resonance Energy TransferGenerationsGlycoproteinsHIV-1HIV-IHIV1Human Immunodeficiency Virus Type 1Human immunodeficiency virus 1ImmuneImmune EvasionImmune systemImmunesL-LysineLengthLysineMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMethodsModelingMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular MachinesMolecular StereochemistryMolecular TargetMonitorOutcomePositionPositioning AttributePredispositionResolutionRoleSamplingScheduleSpecific qualifier valueSpecifiedSpectroscopySpectrum AnalysesSpectrum AnalysisStructureSurfaceSusceptibilityTechniquesTemperatureTestingTimeVaccinesViralViral Gene ProductsViral Gene ProteinsViral ProteinsVirionVirusVirus ParticleWorkbalancebalance functionbiophysical approachesbiophysical equipmentbiophysical foundationbiophysical methodologybiophysical methodsbiophysical principlesbiophysical sciencesbiophysical techniquesbiophysical toolsblock viral entryconformationconformationalconformational stateconformationallyconformationscrosslinkdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblefluorophoreimmune evasiveimmunogenimmunogenicityimprovedinhibit viral entryinhibitormembrane structuremolecular dynamicsresolutionssimulationsingle moleculesingle-molecule FRETsingle-molecule fluorescence resonance energy transfersmFRETsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolethree dimensionalvaccine developmentviral entry blockerviral entry inhibitorviral infectious disease treatmentvirus protein
Description preview
PROJECT SUMMARY
The HIV-1 envelope glycoprotein spike (Env) mediates viral entry into target cells. Because Env is the only
viral protein on the virion surface, it is central to the development of potential vaccines and small-molecule
entry inhibitors. Env is a uniquely flexible molecular machine, and deep understanding of its immunogenicity
and…
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