grant
Combining B. thuringiensis crystal proteins with small molecule anthelmintics to combat parasitic nematode resistance
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 16 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldA suumA. suumAIDS VirusAccountingAcetylcholineAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdultAdult HumanAgricultureAlbendazoleAllelesAllelomorphsAncylostomaAncylostoma (genus)AncylostomatidaeAnemiaAnimalsAnthelminticsAntihelminthic AgentAntihelminthic DrugsAscarisAscaris suumB subtilisB thuringiensisB. subtilisB. thuringiensisBacillus subtilisBacillus thuringiensisBacteriaBiotechBiotechnologyC elegansC. elegansC.elegansCaenorhabditis elegansCanine SpeciesCanis familiarisChildChild YouthChildren (0-21)Cognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCombined Modality TherapyComputer ModelsComputerized ModelsCricetinaeDALYDataDevelopmentDiseaseDisorderDisturbance in cognitionDogsDogs MammalsDomestic HorseDrug CombinationsDrug DesignDrug resistanceDrug usageDrugsEarthEconomic IncomeEconomical IncomeEducationEducational aspectsEquineEquine SpeciesEquus caballusEquus przewalskiiFamily suidaeFoodFormulationFutureGeneralized GrowthGrowthHIVHaemonchusHamstersHamsters MammalsHelminthsHookwormsHorsesHumanHuman Immunodeficiency VirusesImmune responseImpaired cognitionIn VitroIn vivo analysisIncomeIndustrializationInfectionInsecticidesIntestinalIntestinesIvermectinLAV-HTLV-IIILocationLymphadenopathy-Associated VirusM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMalariaMalnutritionMammaliaMammalsMedicalMedicationMiceMice MammalsModelingModern ManMorbidityMultimodal TherapyMultimodal TreatmentMurineMusMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNecatorNematodaNematodesNicotinic Acetylcholine ReceptorsNicotinic ReceptorsNutritional DeficiencyOralOvineOvisPaludismParasite ControlParasite resistanceParasitesParasitic WormsParasitic infectionParasitic nematodePathway interactionsPersonsPharmaceutical PreparationsPharmacologyPhysical FitnessPigsPlanet EarthPlasmodium InfectionsPopulationPredispositionPregnant WomenProbioticsProductivityPropertyProteinsQOLQuality of lifeRecommendationRegulatory approvalResearchResearch DesignResistanceRodentRodentiaRodents MammalsSafetySheepSoilStudy TypeSuidaeSusceptibilitySwineTB infectionTestingTissue GrowthTransgenic OrganismsTransmissionTrichocephalusTrichurisTuberculosisUndernutritionVermifugesVertebrate AnimalsVertebratesVirus-HIVacetylcholine receptor agonistadulthoodadverse pregnancy outcomeantihelminthicassay developmentbenzimidazolebowelcaninecognitive dysfunctioncognitive losscombatcombination therapycombinatorialcombined modality treatmentcombined treatmentcomputational modelingcomputational modelscomputer based modelscomputerized modelingcostdata integrationdesigndesigningdevelopmentaldietary deficiencydisability-adjusted life yearsdisseminated TBdisseminated tuberculosisdomestic dogdrug efficacydrug resistantdrug usedrug/agentexpectant motherexpectant womenexpecting motherexpecting womenexperiencegastrointestinalhost responseimmune system responseimmunoresponseimprovedimproved outcomein vivoin vivo evaluationin vivo testingincomesindividuals who are pregnantinfected with parasitesinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeinsect disease vectorkidsmalnourishedmulti-modal therapymulti-modal treatmentmutantnext generationnovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderontogenyparasite infectionparasite resistantparasitic roundwormpathwaypeople who are pregnantphysical impairmentporcinepregnant femalespregnant motherspregnant peoplepregnant populationsproductivity lossregulatory authorizationregulatory certificationregulatory clearanceresistance in parasiteresistance strainresistance to Drugresistance to Parasiteresistantresistant parasiteresistant strainresistant to Drugresistant to Parasiteroundwormsmall moleculesmall molecule therapeuticsstudy designsuidsynergismtherapeutic targetthose who are pregnanttranscriptomicstransgenictransmission processtuberculosis infectiontuberculous spondyloarthropathyvector controlvertebratawomen who are pregnantyoungster
Description preview
New treatments are urgently needed for parasitic gastrointestinal nematodes (GINs; hookworms, whipworms,
roundworms) that infect ~1.5 billion people and cause significant morbidity in children, pregnant women, and
working adults. The main drug used against GIN in mass drug administration (MDA) is albendazole (ABZ),
with increased use of ivermectin…
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