grant
Combinational targeting histone and RNA modifications in prostate cancer
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 9 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025Activator AppliancesActivator Orthodontic AppliancesAffectAlternate SplicingAlternative RNA SplicingAlternative SplicingAreaB lymphoma Mo MLV insertionBMI1BMI1 geneBenignBiological MarkersBiotechBiotechnologyCancer GenesCancer PatientCancer-Promoting GeneCancersCell BodyCellsCellular ExpansionCellular GrowthClinicalCombined Modality TherapyDNADNA MethylationDataDeoxyribonucleic AcidDevelopmentDrugsEC 2.1.1EnhancersEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpithelium of Human Prostate GlandEventFunction ActivatorFunctional RNAFutureGene ExpressionGene InactivationGene SilencingGene TranscriptionGeneHomologGenesGeneticGenetic TranscriptionHeterograftHeterologous TransplantationHistone-Lysine MethyltransferaseHistone-Lysine N-MethyltransferaseHistonesHomologHomologous GeneHomologueInvestigationL-LysineLysineMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMediatingMedicationMessenger RNAMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Prostate CancerMetastatic TumorMethylationMethyltransferaseMicroRNAsModificationMultimodal TherapyMultimodal TreatmentNeoplasm MetastasisNon-Polyadenylated RNANoncoding RNANontranslated RNAOncogenesOutcomePDX modelPatient derived xenograftPatientsPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlayPolycombProstate CAProstate CancerProstate Carcinoma MetastaticProstate carcinomaProstate malignancyProstatic EpitheliumProstatic carcinomaProtein BiosynthesisProtein Lysine MethyltransferaseProtein Methylase IIIProtein Methyltransferase IIIProteinsRNARNA DecayRNA EditingRNA ExpressionRNA Gene ProductsRNA SplicingRNA StabilityRNA methylationRNA, Messenger, EditingReaderRegulationRelapseReportingResearch DesignResistance developmentResistant developmentRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSamplingSecondary NeoplasmSecondary TumorSolidSolid NeoplasmSolid TumorSpeedSplicingStudy TypeTOP2TOP2ATOP2A geneTP2ATestingTherapeuticTimeTranscriptTranscriptionTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscription RepressorTranscriptional Activator/CoactivatorTranscriptional RepressorTransforming GenesTranslationsTreatment EfficacyTumor PromotionTumor Suppressor ProteinsUntranslated RNAWorkXenograftXenograft procedureXenotransplantationadvanced prostate cancerbio-markersbiologic markerbiomarkercancer initiationcancer metastasiscancer typecarcinoma prostatic cancercell growthcombination therapycombined modality treatmentcombined treatmentdemethylationdesigndesigningdevelop therapydeveloping resistancedevelopmentaldrug/agentepigenetic regulationepigeneticallygain of functiongenetic repressorhistone H3 methyltransferasehistone methylasehistone methylationhistone methyltransferasehistone modificationinhibitorinsightintervention developmentintervention efficacyknock-downknockdownmRNAmRNA DecaymRNA DegradationmRNA StabilitymRNA Transcript DegradationmalignancymenmethylasemiRNAmulti-modal therapymulti-modal treatmentmutantneoplasm/cancernew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnoncodingnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpatient derived xenograft modelpharmaceuticalpromoterpromotorprostate cancer cellprostate cancer progressionprostate tumor cellprotein synthesisrecruitresistance to therapyresistant to therapysocial rolestudy designtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic efficacytherapeutic resistancetherapeutic targettherapy developmenttherapy efficacytherapy resistanttranscriptional silencingtranslationtransmethylasetreatment developmenttreatment resistancetumor cell metastasistumor growthtumor suppressorunderstudied cancerxeno-transplantxeno-transplantation
Description preview
Abstract
Prostate cancer is one of the most common cancers among men, and although it can successfully be
treated in some men, others develop resistance to therapies and can relapse. Thus, it is prudent to discover
new therapeutic targets and develop therapeutic strategies that utilize already developed therapies to expedite
the development of…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click