grant
Colonoscopy augmentation with Fluorescence Lifetime Imaging (FLIm): colorectal cancer detection in humans
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 8 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAbscissionAccuracy of DiagnosisAddressAdenomatous PolypsAdultAdult HumanAlgorithmic AnalysesAlgorithmic AnalysisAlgorithmsAnalyses of AlgorithmsAnalysis of AlgorithmsAreaBedsBenignBiochemicalBiopsyBody TissuesCRC screeningCancer CauseCancer EtiologyCancer InductionCancerousCancersCell Communication and SignalingCell SignalingCessation of lifeCharacteristicsClassificationClinicalClinical ManagementColonColon or RectumColonoscopesColonoscopyColorectalColorectal CancerComplexContrast AgentContrast DrugsContrast MediaContrast-Enhancing LesionDataData AnalysesData AnalysisData BasesData SetDatabasesDeathDecision MakingDetectionDiagnosisDiameterDiseaseDisorderEarly DiagnosisEndoscopyEnhancing LesionEnvironmentEvaluationExcisionExtirpationFLIM imagingFeedbackFiber OpticsFluorescenceGadolinium-Enhancing LesionGd-Enhancing LesionGoalsHumanHyperplastic PolypImageImaging DeviceImaging InstrumentImaging ToolImaging technologyIn Situ LesionIncidenceInflammationInflammatoryIntermediary MetabolismIntracellular Communication and SignalingLabelLaser ElectromagneticLaser RadiationLasersLengthLesionLibrariesLightMachine LearningMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMapsMeasuresMetabolic ProcessesMetabolismMetaplastic PolypMethodsModern ManMonitorMotilityMucosaMucosal TissueMucous MembraneOutcomePathologyPatient CarePatient Care DeliveryPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePhotoradiationPhysiologic pulsePolypsPositionPositioning AttributeProceduresPropertyPulseRadiopaque MediaRemovalResearchResectedSamplingSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingStagingStructural defectStructural malformationStructureSurgical RemovalSystemSystematicsTechniquesTechnologyTimeTissuesValidationVisualizationWorkadulthoodbiological signal transductioncancer diagnosiscarcinogenesiscare for patientscare of patientscaring for patientsclinical decision-makingclinical practiceclinical relevanceclinically relevantcolorectal cancer detectioncolorectal cancer early detectioncolorectal cancer screeningcolorectumcost effectivedata acquisitiondata acquisitionsdata basedata interpretationdetect colorectal cancerdiagnostic accuracyearly detectionendoscopic imagingfluorescence life-time imagingfluorescence life-time imaging microscopyfluorescence lifetime imagingfluorescence lifetime imaging microscopyglobal healthimage-based methodimagingimaging in vivoimaging methodimaging modalityimprovedin vivoin vivo fluorescencein vivo imaginginsightmachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmalignancymetermortalityneoplasm/cancernew approachesnovelnovel approachesnovel strategiesnovel strategypatient oriented outcomespolypoid adenomaprecancerprecancerouspremalignantreal-time imagesrealtime imageresectionscreeningscreeningsstructural abnormalitiesstructural anomaliestargeted imagingthree dimensionaltooluser-friendlyvalidations
Description preview
PROJECT SUMMARY
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality globally, with current screening
techniques, such as colonoscopy, demonstrating limitations in accurately detecting subtle structural
abnormalities and biochemical changes in colorectal lesions. These limitations contribute to missed diagnoses
and…
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