grant
Cognitive heterogeneity in those with high Alzheimer's Disease Risk
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 30 Sept 2018Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAD biological markerAD biomarkerAD dementiaAD pathologyAD related biomarkerAD riskAD risk factorAD therapyAD treatmentAPOEAdoptionAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's diagnosisAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease diagnosisAlzheimer's disease pathologyAlzheimer's disease related biomarkerAlzheimer's disease riskAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's related biomarkerAlzheimer's therapyAlzheimers DementiaAlzheimer’s biological markerAmentiaAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinApo-EApoE proteinApolipoprotein EAutopsyAβBackBehavioralBiological MarkersBlood PlasmaBody TissuesCardiovascular DiseasesCausalityCell Communication and SignalingCell SignalingCharacteristicsClassificationClinicalCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalCommunitiesDataData AnalyticsData BasesDatabasesDementiaDiseaseDisease ProgressionDisorderDisturbance in cognitionDorsumEarly InterventionEtiologyFemaleFramingham Heart StudyGeneticGoalsGrainHeterogeneityImpaired cognitionIndividualInterventionIntracellular Communication and SignalingLearningLinkLiteratureMR ImagingMR TomographyMRIMRI ScansMRIsMT-bound tauMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModelingNIAAANMR ImagingNMR TomographyNational Institute on Alcohol Abuse and AlcoholismNatureNerve DegenerationNeuron DegenerationNeuropsychologic TestsNeuropsychological TestsNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPETSCANPETTParticipantPersonsPlasmaPlasma SerumPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaRad.-PETReportingResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRisk AssessmentRisk FactorsSignal TransductionSignal Transduction SystemsSignalingStandardizationStatistical MethodsSystematicsTauopathiesTimeTissuesTranslatingVascular DiseasesVascular DisorderZeugmatographya beta peptideabetaalzheimer riskamyloid betaamyloid-b proteinbeta amyloid fibrilbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseaseblood vessel disorderbrain MR imagingbrain MRIbrain magnetic resonance imagingcardiovascular disordercausationcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingclinical predictorscognitive abilitycognitive changecognitive dysfunctioncognitive losscognitive performancecohortdata basedeep learningdeep learning methoddeep learning strategydetection methoddetection proceduredetection techniquedigitaldigital measuredigital metricdisease causationdisease riskdisorder riskeffective therapyeffective treatmenthigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationin vivoindexingmicrotubule bound taumicrotubule-bound taumild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmulti-modal datamulti-modal datasetsmulti-modalitymultimodal datamultimodal datasetsmultimodalitynecropsyneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologic tauneuropathological tauneuropsychologicnovelold ageperformance testspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempre-clinicalpreclinicalprimary degenerative dementiaprospectiverisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'ssenile dementia of the Alzheimer typesexsoluble amyloid precursor proteinstatistic methodstautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathythree dimensionalvascular dysfunctionvascular risk factorvasculopathyτ Proteins♀
Description preview
PROJECT SUMMARY
The insidious nature of Alzheimer’s disease (AD) spans decades and adds complexity to detect the disease
earlier in its course. A significant consideration is that those identified as at risk for AD may not necessarily
develop clinically expressed disease. Traditional methods for detecting behavioral indices associated with
those…
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