grant
Coding in Auditory Neurons: Effects of Amino Acids
Organization SOUTHERN ILLINOIS UNIVERSITY SCH OF MEDLocation SPRINGFIELD, UNITED STATESPosted 1 Aug 1979Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY202665 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldACh ReceptorsAcetylcholineAcetylcholine ReceptorsAcousticsAffectAged 65 and OverAgingAmino AcidsAnesthesiaAnesthesia proceduresAttentionAuditoryAuditory CortexAuditory areaAuditory systemAwardBehavioralBindingBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCholinergic ReceptorsCholinoceptive SitesCholinoceptorsCodeCoding SystemCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommon Rat StrainsComplexDataDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderDisturbance in cognitionDorsalDrug DesignDrug TargetingDrug TherapyDrugsElderlyElectrophysiologyElectrophysiology (science)EncephalonExposure toFISH TechnicFISH TechniqueFISH analysisFISH assayFemaleFluorescence In Situ HybridizationFluorescent in Situ HybridizationFutureGlutamatesGrantHearingImpaired cognitionIn VitroIndividualIndustrializationInferior ColliculusIntracellular Communication and SignalingKnowledgeL-GlutamateLocationMedial geniculate bodyMediatingMedicationMental DepressionModelingMolecular InteractionNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurotransmittersNicotinic Acetylcholine ReceptorsNicotinic ReceptorsNorway RatsNucleusOlder PopulationPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyPonsPons CerebelliPons VaroliiPontinePontine structurePopulationPosterior Quadrigeminal BodyPresbyacusisPresbycusisPropertyRatRats MammalsRattusRattus norvegicusReceptor ActivationReceptor ProteinResearch ResourcesResistanceResourcesSensorySex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSliceSocial isolationSpeechStimulusStructureSystemTegmentum MesencephaliThalamic structureThalamusTranscriptUnited StatesWithdrawalabove age 65acetylcholine receptor agonistadult youthadvanced ageafter age 65age 65 and greaterage 65 and olderage 65 or olderageage associatedage associated alterationsage associated changesage associated effectsage associated hearing lossage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage effectage induced alterationsage induced changesage induced hearing lossage linkedage of 65 years onwardage relatedage related alterationsage related changesage related decline in hearingage related effectsage related hearing deficitsage related hearing impairmentage related hearing lossage specificage specific alterationsage specific changesagedaged 65 and greateraged 65+aged ≥65aging associated alterationsaging associated changesaging associated hearing lossaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging effectaging induced alterationsaging induced changesaging induced hearing lossaging related alterationsaging related changesaging related decline in hearingaging related hearing deficitsaging related hearing impairmentaging related hearing lossaging specific alterationsaging specific changesalterations with ageaminoacidantagonismantagonistattention modulationattentional modulationauditory pathwayauditory thalamusawakebiological signal transductioncell typechanges with agecholinergiccognitive dysfunctioncognitive lossdepressiondesigndesigningdevelopmentaldrug developmentdrug interventiondrug treatmentdrug/agentelectrophysiologicalgeriatricglutamatergichuman old age (65+)impact of ageimprovedin vivoinfluence of ageinformation processingjuvenile animalmaleneuronalnovelolder groupsolder individualsolder personoptogeneticsover 65 yearspatch clamppharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspostsynapticpreferencepresynapticradioligandreceptorreceptor functionresistantresponsesenior citizensex based differencessex-dependent differencessex-related differencessex-specific differencessocialsynapse functionsynaptic functiontegmentumthalamicyoung adultyoung adult ageyoung adulthoodyoung animal≥65 years♀♂
Description preview
PROJECT SUMMARY
Age-related hearing loss (ARHL) is a complex disorder affecting between 50-70% of the United States population
aged 65 or older. In public settings, seniors frequently have great difficulty understanding speech, which can
lead to withdrawal from social activities, depression and cognitive decline. All individuals and especially the…
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