grant
Cochlear resident tissue macrophages in normal cochlear development and the response to CMV infection
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years oldAcuteAdultAdult HumanAffectArchitectureAudiogramAudiometric TestAudiometryAuditoryAuditory systemAutomobile DrivingAutoregulationBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD115CD115 GeneCMVCMV infectionCSF1RCSF1R geneCSFMRCell BodyCellsCochleaCochlear OrganColony Stimulating Factor 1 Receptor GeneCytomegalic Inclusion DiseaseCytomegalovirusCytomegalovirus InfectionsDataDevelopmentDiseaseDisorderDysfunctionEngineering / ArchitectureEquilibriumFunctional disorderGene TranscriptionGeneralized GrowthGeneticGenetic TranscriptionGoalsGrowthGustationHCMVHealthHearingHearing LossHearing TestsHistologicHistologicallyHomeostasisHypoacusesHypoacusisImmuneImmune RegulatorsImmune infiltratesImmune responseImmunesImmunityImmunomodulatorsImpairmentInclusion DiseaseInfectionInflammationKnowledgeLanguageLifeMacrophageMapsMeasuresMediatingMediatorMiceMice MammalsMicroscopyMissionModelingMurineMusMφNIDCDNational Institute on Deafness and Other Communication DisordersNeonatalOlfactionPathogenesisPathogenicityPatientsPatternPerinatal InfectionPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPredispositionPublic HealthRNA ExpressionRegulationResearchResearch SupportResolutionRoleSalivary Gland Virus DiseaseSalivary Gland VirusesSensorineural DeafnessSensorineural Hearing LossSensory Hearing LossShapesSmellSmell PerceptionSourceSpeechSusceptibilityTasteTaste PerceptionTestingTissue GrowthTissuesTranscriptionViral DiseasesVirus DiseasesVoiceWorkacute infectionadulthoodauditory testsbalancebalance functionc-FMSc-fms Genesc-fms Proto-Oncogenescochlear developmentcongenital CMVcongenital cytomegaloviruscongenital cytomegalovirus infectioncongenital infectioncytomegalovirus groupdefined contributiondevelopmentaldrivingdysfunctional hearingfetalgustatory perceptiongustatory processinggustatory responsehearing assessmenthearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthearing loss therapyhearing loss treatmenthost responseimmune cell infiltrateimmune modulatorsimmune system responseimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimmunoresponseimprovedinfant infectioninfected infantinjury to tissueinnovateinnovationinnovativeintrauterine infectionmouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetodor perceptionolfactory perceptionontogenypathophysiologyperinatal developmentperinatal periodperinatal phasepostnatalresolutionsresponsesensorineural hearing impairmentsocial rolespatial and temporalspatial temporalspatiotemporaltaste processingtaste responsetissue injurytranscriptomicstreatment for hearing lossviral infectionvirus infectionvirus-induced disease
Description preview
PROJECT SUMMARY / ABSTRACT
Congenital cytomegalovirus (CMV) infection can lead to sensorineural hearing loss (SNHL) long after resolution
of acute infection, implicating lasting alterations to tissue immunity, but the underlying pathogenic mechanisms
remain poorly understood. The long-term goal of this project is to define the mechanisms by which…
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